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Tbio
PLXNC1
Plexin-C1

Protein Summary
Description
Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity). This gene encodes a member of the plexin family. Plexins are transmembrane receptors for semaphorins, a large family of proteins that regulate axon guidance, cell motility and migration, and the immune response. The encoded protein and its ligand regulate melanocyte adhesion, and viral semaphorins may modulate the immune response by binding to this receptor. The encoded protein may be a tumor suppressor protein for melanoma. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258526
  • ENSP00000258526
  • ENSG00000136040

Symbol
  • VESPR
  • CD232
  • VESPR
  • PLXN-C1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
protein domain
0.97
PubMedID
0.96
transcription factor binding site profile
0.74
transcription factor
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.08   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 111   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.08   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.1
58.9
1
1
0
1.1
21.5
chloride measurement
1
1
1
17.8
sodium measurement
1
1
1
15.8
eosinophil count
2
1
2
12.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
58.9
0
1.1
21.5
chloride measurement
1
17.8
sodium measurement
1
15.8
eosinophil count
2
12.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
plexin C1
VGNC:5538
452130
Macaque
plexin C1
711320
Mouse
MGI:1890127
54712
Rat
RGD:1307420
362873
Dog
plexin C1
VGNC:44725
100685138
Species
Name
OMA
EggNOG
Inparanoid
Chimp
plexin C1
Macaque
plexin C1
Mouse
Rat
Dog
plexin C1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O60486-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Other semaphorin interactions
Reactome
Semaphorin interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Other semaphorin interactions
Semaphorin interactions
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (70)
1 – 10 of 70
SEMA7A
Tbio
Novelty:  0.00741605
Score:  0.998
Data Source:  Reactome,STRINGDB
SEMA5B
Tbio
Novelty:  0.0151789
Score:  0.917
Data Source:  STRINGDB
SEMA6B
Tbio
Novelty:  0.01461717
Score:  0.916
Data Source:  STRINGDB
SEMA4D
Tbio
Novelty:  0.0043592
Score:  0.915
Data Source:  STRINGDB
SEMA3F
Tbio
Novelty:  0.00676786
Score:  0.915
Data Source:  STRINGDB
SEMA3B
Tbio
Novelty:  0.00626976
Score:  0.915
Data Source:  STRINGDB
SEMA6A
Tbio
Novelty:  0.00624456
Score:  0.915
Data Source:  STRINGDB
SEMA3E
Tbio
Novelty:  0.00936004
Score:  0.914
Data Source:  STRINGDB
SEMA3D
Tbio
Novelty:  0.00821843
Score:  0.912
Data Source:  STRINGDB
SEMA3C
Tbio
Novelty:  0.00828813
Score:  0.912
Data Source:  STRINGDB
Publication Statistics
PubMed Score  40.08

PubMed score by year
PubTator Score  12.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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