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Tbio
ZIC3
Zinc finger protein ZIC 3

Protein Summary
Description
Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This nuclear protein probably functions as a transcription factor in early stages of left-right body axis formation. Mutations in this gene cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287538
  • ENSP00000287538
  • ENSG00000156925
  • ENST00000370606
  • ENSP00000359638

Symbol
  • ZNF203
  • HTX
  • HTX1
  • ZNF203
  • VACTERLX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
molecular function
0.86
phenotype
0.74
biological process
0.71
virus perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.91   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 236   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.91   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 236   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (75)
NANOG
Tbio
Family:  TF
Novelty:  0.00054893
Score:  0.975
Data Source:  STRINGDB
SOX2
Tbio
Family:  TF
Novelty:  0.00037089
Score:  0.967
Data Source:  STRINGDB
POU5F1
Tbio
Family:  TF
Novelty:  0.00033974
Score:  0.957
Data Source:  STRINGDB
PASD1
Tbio
Novelty:  0.1125027
Score:  0.924
Data Source:  STRINGDB
ACVR2B
Tchem
Family:  Kinase
Novelty:  0.00555742
Score:  0.823
Data Source:  STRINGDB
LEFTY2
Tbio
Novelty:  0.01038653
Score:  0.816
Data Source:  STRINGDB
NODAL
Tbio
Novelty:  0.01033642
Score:  0.816
Data Source:  STRINGDB
GPR31
Tbio
Family:  GPCR
Novelty:  0.09160693
Score:  0.811
Data Source:  STRINGDB
TDGF1
Tbio
Novelty:  0.00527099
Score:  0.727
Data Source:  STRINGDB
OTX2
Tbio
Family:  TF
Novelty:  0.0024536
Score:  0.689
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (192)
Developmental Biology (R-HSA-1266738)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Reactome
Transcriptional regulation of pluripotent stem cells
Name
Explore in Pharos
Explore in Source
Developmental Biology
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Transcriptional regulation of pluripotent stem cells
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:106676
22773
Rat
RGD:1561261
367944
Dog
Zic family member 3
VGNC:48634
492171
Horse
Zic family member 3
VGNC:25237
100054537
Cow
Zic family member 3
VGNC:37186
541035
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
Zic family member 3
Horse
Zic family member 3
Cow
Zic family member 3
Publication Statistics
PubMed Score 121.91
PubMed score by year
PubTator Score 111.00
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title