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Tbio
DLX3
Homeobox protein DLX-3

Protein Summary
Description
Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis. Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. Trichodentoosseous syndrome (TDO), an autosomal dominant condition, has been correlated with DLX3 gene mutation. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 17. Mutations in this gene have been associated with the autosomal dominant conditions trichodentoosseous syndrome and amelogenesis imperfecta with taurodontism. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000434704
  • ENSP00000389870
  • ENSG00000064195

Symbol
  • AI4
  • TDO
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.95
protein domain
0.85
PubMedID
0.67
transcription factor binding site profile
0.66
tissue
0.59


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.58   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 231   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.58   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 231   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
distal-less homeobox 3
VGNC:9259
455110
Macaque
distal-less homeobox 3
700831
Mouse
MGI:94903
13393
Rat
RGD:1304875
287638
Dog
distal-less homeobox 3
VGNC:39991
491073
Species
Name
OMA
EggNOG
Inparanoid
Chimp
distal-less homeobox 3
Macaque
distal-less homeobox 3
Mouse
Rat
Dog
distal-less homeobox 3
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O60479-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (114)
Items per page:
1 – 5 of 114
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
WikiPathways
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
WikiPathways
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
WikiPathways
Myometrial Relaxation and Contraction Pathways
WikiPathways
Myometrial Relaxation and Contraction Pathways
Name
Explore in Pharos
Explore in Source
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Myometrial Relaxation and Contraction Pathways
Myometrial Relaxation and Contraction Pathways
Gene Ontology Terms (11)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (85)
1 – 10 of 85
MEIS1
Tbio
Family: TF
Novelty: 0.00480433
Score: 0.971
Data Source: STRINGDB
MEIS2
Tbio
Family: TF
Novelty: 0.01393828
Score: 0.968
Data Source: STRINGDB
WDR72
Tbio
Novelty: 0.07576018
Score: 0.794
Data Source: STRINGDB
BMP2
Tbio
Novelty: 0.00016974
Score: 0.733
Data Source: STRINGDB
SLC24A4
Tbio
Family: Transporter
Novelty: 0.02745216
Score: 0.72
Data Source: STRINGDB
DSPP
Tbio
Novelty: 0.00116404
Score: 0.699
Data Source: STRINGDB
FOXI2
Tbio
Family: TF
Novelty: 0.19133576
Score: 0.658
Data Source: STRINGDB
ENAM
Tbio
Novelty: 0.00593293
Score: 0.634
Data Source: STRINGDB
LAMB3
Tbio
Novelty: 0.00717673
Score: 0.633
Data Source: STRINGDB
BGLAP
Tbio
Novelty: 0.00009678
Score: 0.629
Data Source: STRINGDB
Publication Statistics
PubMed Score  126.58

PubMed score by year
PubTator Score  67.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer