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Tbio
MAN1A2
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB

Protein Classes
Protein Summary
Description
Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2). Alpha-mannosidases function at different stages of N-glycan maturation in mammalian cells. See MAN2A1 (MIM 154582) for general information.[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356554
  • ENSP00000348959
  • ENSG00000198162

Symbol
  • MAN1B
  • MAN1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
transcription factor perturbation
0.84
histone modification site profile
0.75
transcription factor binding site profile
0.74
cellular component
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.73   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 81   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.73   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
4
5
98.2
mean platelet volume
3
3
3
97.1
reticulocyte count
7
2
7
90.7
monocyte count
2
2
2
89.3
platelet count
1
1
1
82.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
5
98.2
mean platelet volume
3
97.1
reticulocyte count
7
90.7
monocyte count
2
89.3
platelet count
1
82.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mannosidase alpha class 1A member 2
VGNC:8070
457159
Mouse
MGI:104676
17156
Rat
RGD:1309767
295319
Dog
mannosidase alpha class 1A member 2
VGNC:42943
483141
Horse
mannosidase alpha class 1A member 2
VGNC:19908
100066466
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mannosidase alpha class 1A member 2
Mouse
Rat
Dog
mannosidase alpha class 1A member 2
Horse
mannosidase alpha class 1A member 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O60476-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (15)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Intra-Golgi traffic
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Intra-Golgi and retrograde Golgi-to-ER traffic
Intra-Golgi traffic
Membrane Trafficking
Metabolism of proteins
Protein-Protein Interactions (98)
1 – 10 of 98
TNFSF18
Tbio
Novelty:  0.01423949
p_int:  0.999912829
p_ni:  0.000087169
p_wrong:  2e-9
Data Source:  BioPlex
CLDND1
Tbio
Novelty:  0.06681793
p_int:  0.999882475
p_ni:  0.000117525
Score:  0.209
Data Source:  BioPlex,STRINGDB
FAM241A
Tdark
Novelty:  1.04041354
p_int:  0.999809548
p_ni:  0.000190449
p_wrong:  3e-9
Data Source:  BioPlex
CLU
Tbio
Novelty:  0.00054776
p_int:  0.924195613
p_ni:  0.075801442
p_wrong:  0.000002945
Data Source:  BioPlex
CD1B
Tbio
Novelty:  0.00102701
p_int:  0.921426042
p_ni:  0.078573958
Data Source:  BioPlex
SCARA3
Tbio
Novelty:  0.00621523
p_int:  0.921055675
p_ni:  0.078933834
p_wrong:  0.000010491
Score:  0.164
Data Source:  BioPlex,STRINGDB
C5AR2
Tbio
Family:  GPCR
Novelty:  0.01193736
p_int:  0.915172869
p_ni:  0.084827131
Data Source:  BioPlex
CD1E
Tbio
Novelty:  0.00171622
p_int:  0.907977437
p_ni:  0.092017865
p_wrong:  0.000004698
Data Source:  BioPlex
SCGB2A2
Tbio
Novelty:  0.01594053
p_int:  0.902705262
p_ni:  0.097287411
p_wrong:  0.000007327
Data Source:  BioPlex
CHRNB4
Tclin
Family:  IC
Novelty:  0.01151716
p_int:  0.860702199
p_ni:  0.139295272
p_wrong:  0.00000253
Data Source:  BioPlex
Publication Statistics
PubMed Score  6.73

PubMed score by year
PubTator Score  34.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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