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Tbio
DSCAM
Down syndrome cell adhesion molecule

Protein Summary
Description
Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies (PubMed:10925149). Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. In spinal chord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding (PubMed:18585357, PubMed:19196994). Enhances netrin-induced phosphorylation of PAK1 and FYN (PubMed:15169762). Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38 (PubMed:18585357, PubMed:19196994). Adhesion molecule that promotes lamina-spe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000400454
  • ENSP00000383303
  • ENSG00000171587

Symbol
  • CHD2
  • CHD2-42
  • CHD2-52
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
protein domain
0.85
phenotype
0.8
small molecule perturbation
0.75
biological process
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 267.37   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 267.37   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (97)
NTN1
Tbio
Novelty:  0.00183678
Score:  0.987
Data Source:  Reactome,STRINGDB
DCC
Tbio
Novelty:  0.01273911
Score:  0.953
Data Source:  Reactome,STRINGDB
PAK1
Tchem
Family:  Kinase
Novelty:  0.00411227
Score:  0.952
Data Source:  Reactome,STRINGDB
MAPK8
Tchem
Family:  Kinase
Novelty:  0.00055723
Score:  0.925
Data Source:  Reactome,STRINGDB
MAPK14
Tchem
Family:  Kinase
Novelty:  0.00045138
Score:  0.923
Data Source:  STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.905
Data Source:  Reactome,STRINGDB
MAPK11
Tchem
Family:  Kinase
Novelty:  0.00545217
Score:  0.904
Data Source:  STRINGDB
MAPK13
Tchem
Family:  Kinase
Novelty:  0.01071621
Score:  0.902
Data Source:  STRINGDB
MAPK12
Tchem
Family:  Kinase
Novelty:  0.00835017
Score:  0.902
Data Source:  STRINGDB
TBCD
Tbio
Novelty:  0.01161221
Score:  0.812
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
DSCAM interactions
Reactome
Developmental Biology
Reactome
Netrin-1 signaling
Name
Explore in Pharos
Explore in Source
Axon guidance
DSCAM interactions
Developmental Biology
Netrin-1 signaling
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
3.8
60.5
body mass index
1
1
1
44.2
fasting blood glucose measurement
1
1
0
6.8
31.4
body height
1
1
1
29
feeling nervous measurement
1
1
0
5.7
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
3.8
60.5
body mass index
1
44.2
fasting blood glucose measurement
0
6.8
31.4
body height
1
29
feeling nervous measurement
0
5.7
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1196281
13508
Rat
RGD:619992
171119
Dog
DS cell adhesion molecule
VGNC:40102
487768
Horse
DS cell adhesion molecule
100058783
Cow
DS cell adhesion molecule
VGNC:28215
100337016
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
DS cell adhesion molecule
Horse
DS cell adhesion molecule
Cow
DS cell adhesion molecule
Publication Statistics
PubMed Score 267.37
PubMed score by year
PubTator Score 61.56
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title