Tbio GSDME Gasdermin-E

Protein Summary

Description

Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 (PubMed:16897187, PubMed:18223688). Gasdermin-E, N-terminal: Switches CASP3-mediated apoptosis induced by TNF or danger signals, such as chemotherapy drugs, to pyroptosis (PubMed:28459430, PubMed:27281216). Produced by the cleavage of GSDME by CASP3, perforates cell membrane and thereby induces pyroptosis. After cleavage, moves to the plasma membrane where it strongly binds to inner leaflet lipids, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate (PubMed:28459430). Mediates secondary necrosis downstream of the mitochondrial apoptotic pathway and CASP3 activation as well as in response to viral agents (PubMed:28045099). Exhibits bactericidal activity (PubMed:27281216). Hearing impairment is a heterogeneous condition with over 40 loci described. The protein encoded by this gene is expressed in fetal cochlea, however, its function is not known. Nonsyndromic hearing impairment is associated with a mutation in this gene. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O60443
• A4D156
• B2RAX9
• B3KT05
• O14590
• Q08AQ8
• Q9UBV3

Gene Name

• GSDME

Ensembl ID

• ENST00000342947
• ENSP00000339587
• ENSG00000105928
• ENST00000409775
• ENSP00000386670
• ENST00000409970
• ENSP00000387119
• ENST00000419307
• ENSP00000401332
• ENST00000645220
• ENSP00000494186

Symbol

• DFNA5
• ICERE1
• DFNA5
• ICERE-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.93   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 191   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.93   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GlyGen

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ARCHS4

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (71)

Explore Interacting Targets

1 – 10 of 71

• See Interactions on String-DB

EPHA1

Tchem

Family:  Kinase

Novelty:  0.00136672

p_int:  0.999979601

p_ni:  0.000020399

Data Source:  BioPlex

SIGLECL1

Tdark

p_int:  0.999926481

p_ni:  0.000073519

Data Source:  BioPlex

SCN2B

Tbio

Family:  IC

Novelty:  0.03773629

p_int:  0.996849733

p_ni:  0.003123788

p_wrong:  0.000026479

Data Source:  BioPlex

C16orf58

Tdark

Novelty:  0.34461652

p_int:  0.994659614

p_ni:  0.005340362

p_wrong:  2.4e-8

Data Source:  BioPlex

PLEC

Tbio

Novelty:  0.00223244

p_int:  0.994392417

p_ni:  0.005607583

Score:  0.167

Data Source:  BioPlex,STRINGDB

MUL1

Tbio

Family:  Enzyme

Novelty:  0.00841786

p_int:  0.990596442

p_ni:  0.009403556

p_wrong:  1e-9

Score:  0.181

Data Source:  BioPlex,STRINGDB

ZSCAN29

Tdark

Family:  TF

Novelty:  1.70466621

p_int:  0.93191319

p_ni:  0.067614418

p_wrong:  0.000472393

Score:  0.189

Data Source:  BioPlex,STRINGDB

SLC27A2

Tbio

Family:  Transporter

Novelty:  0.01436035

p_int:  0.927130456

p_ni:  0.072869544

Data Source:  BioPlex

GPAT4

Tbio

Family:  Enzyme

Novelty:  0.03409111

p_int:  0.925531832

p_ni:  0.074468168

Score:  0.297

Data Source:  BioPlex,STRINGDB

TPST2

Tbio

Family:  Enzyme

Novelty:  0.02551048

p_int:  0.873450591

p_ni:  0.126387245

p_wrong:  0.000162164

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (15)

Functions (2)

Components (3)

Processes (10)

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GO Term	Evidence	Assigned by
cardiolipin binding	Inferred from Direct Assay (IDA)	UniProtKB
phosphatidylinositol-4,5-bisphosphate binding	Inferred from Direct Assay (IDA)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (12)

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5

1 – 5 of 12

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mathematical ability	EFO_0004875	2	2	2		72.8
schizophrenia	EFO_0000692	3	3	1	1.1	61.8
self reported educational attainment	EFO_0004784	2	2	2		60.1
wellbeing measurement	EFO_0007869	3	2	3		57.1
bipolar disorder	EFO_0000289	2	2	1	1	52

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5

1 – 5 of 12

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mathematical ability	EFO_0004875	2		72.8
schizophrenia	EFO_0000692	1	1.1	61.8
self reported educational attainment	EFO_0004784	2		60.1
wellbeing measurement	EFO_0007869	3		57.1
bipolar disorder	EFO_0000289	1	1	52

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cell membrane
Complete proteome
Cytoplasm
Deafness
Disulfide bond
Membrane
Necrosis
Non-syndromic deafness
Polymorphism

GWAS Trait Find Similar Targets

No Header	No Header
biological sex
bipolar disorder
depressive symptom measurement
intelligence
mathematical ability
neuroticism measurement
schizophrenia
self reported educational attainment
smoking status measurement
systolic blood pressure

MGI Phenotype Find Similar Targets

No Header	No Header
hearing/vestibular/ear phenotype
homeostasis/metabolism phenotype
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	gasdermin E	VGNC:9066	463295
Macaque	gasdermin E		703441
Mouse	gasdermin E	MGI:1889850	54722
Dog	gasdermin E	VGNC:39911	611223
Horse	gasdermin E	VGNC:17143	100033992

Species	Name	OMA	EggNOG	Inparanoid
Chimp	gasdermin E
Macaque	gasdermin E
Mouse	gasdermin E
Dog	gasdermin E
Horse	gasdermin E

Publication Statistics

PubMed Score 118.93

PubMed score by year

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PubTator Score 42.44

PubTator score by year

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Related Publications

Text Mined References (41)

GeneRif Annotations (24)

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PMID	Year	Title