Protein Summary
Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 (PubMed:16897187, PubMed:18223688). Gasdermin-E, N-terminal: Switches CASP3-mediated apoptosis induced by TNF or danger signals, such as chemotherapy drugs, to pyroptosis (PubMed:28459430, PubMed:27281216). Produced by the cleavage of GSDME by CASP3, perforates cell membrane and thereby induces pyroptosis. After cleavage, moves to the plasma membrane where it strongly binds to inner leaflet lipids, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate (PubMed:28459430). Mediates secondary necrosis downstream of the mitochondrial apoptotic pathway and CASP3 activation as well as in response to viral agents (PubMed:28045099). Exhibits bactericidal activity (PubMed:27281216). Hearing impairment is a heterogeneous condition with over 40 loci described. The protein encoded by this gene is expressed in fetal cochlea, however, its function is not known. Nonsy ...more
- ENST00000342947
- ENSP00000339587
- ENSG00000105928
- ENST00000409775
- ENSP00000386670
- ENST00000409970
- ENSP00000387119
- ENST00000419307
- ENSP00000401332
- ENST00000645220
- ENSP00000494186
- DFNA5
- ICERE1
- DFNA5
- ICERE-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 118.93 (req: < 5)
Gene RIFs: 24 (req: <= 3)
Antibodies: 191 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 118.93 (req: >= 5)
Gene RIFs: 24 (req: > 3)
Antibodies: 191 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (71)
EPHA1
Family: Kinase
Novelty: 0.00136672
p_int: 0.999979601
p_ni: 0.000020399
Data Source: BioPlex
SCN2B
Family: IC
Novelty: 0.03773629
p_int: 0.996849733
p_ni: 0.003123788
p_wrong: 0.000026479
Data Source: BioPlex
C16orf58
Novelty: 0.34461652
p_int: 0.994659614
p_ni: 0.005340362
p_wrong: 2.4e-8
Data Source: BioPlex
PLEC
Novelty: 0.00223244
p_int: 0.994392417
p_ni: 0.005607583
Score: 0.167
Data Source: BioPlex,STRINGDB
MUL1
Family: Enzyme
Novelty: 0.00841786
p_int: 0.990596442
p_ni: 0.009403556
p_wrong: 1e-9
Score: 0.181
Data Source: BioPlex,STRINGDB
ZSCAN29
Family: TF
Novelty: 1.70466621
p_int: 0.93191319
p_ni: 0.067614418
p_wrong: 0.000472393
Score: 0.189
Data Source: BioPlex,STRINGDB
SLC27A2
Family: Transporter
Novelty: 0.01436035
p_int: 0.927130456
p_ni: 0.072869544
Data Source: BioPlex
GPAT4
Family: Enzyme
Novelty: 0.03409111
p_int: 0.925531832
p_ni: 0.074468168
Score: 0.297
Data Source: BioPlex,STRINGDB
TPST2
Family: Enzyme
Novelty: 0.02551048
p_int: 0.873450591
p_ni: 0.126387245
p_wrong: 0.000162164
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (15)
Functions (2)
Components (3)
Processes (10)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
mathematical ability | 2 | 2 | 2 | 72.8 | |||||
3 | 3 | 1 | 1.1 | 61.8 | |||||
self reported educational attainment | 2 | 2 | 2 | 60.1 | |||||
wellbeing measurement | 3 | 2 | 3 | 57.1 | |||||
2 | 2 | 1 | 1 | 52 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mathematical ability | 2 | 72.8 | |||||
1 | 1.1 | 61.8 | |||||
self reported educational attainment | 2 | 60.1 | |||||
wellbeing measurement | 3 | 57.1 | |||||
1 | 1 | 52 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | gasdermin E | VGNC:9066 | 463295 | |||||
Macaque | gasdermin E | 703441 | ||||||
Mouse | MGI:1889850 | 54722 | ||||||
Dog | gasdermin E | VGNC:39911 | 611223 | |||||
Horse | gasdermin E | VGNC:17143 | 100033992 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | gasdermin E | |||||
Macaque | gasdermin E | |||||
Mouse | ||||||
Dog | gasdermin E | |||||
Horse | gasdermin E | |||||
Publication Statistics
PubMed Score 118.93
PubMed score by year
PubTator Score 42.44
PubTator score by year
Related Publications
Text Mined References (41)
GeneRif Annotations (24)
Items per page:
0 of 0
PMID | Year | Title |
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