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Tbio
GSDME
Gasdermin-E

Protein Summary
Description
Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 (PubMed:16897187, PubMed:18223688). Gasdermin-E, N-terminal: Switches CASP3-mediated apoptosis induced by TNF or danger signals, such as chemotherapy drugs, to pyroptosis (PubMed:28459430, PubMed:27281216). Produced by the cleavage of GSDME by CASP3, perforates cell membrane and thereby induces pyroptosis. After cleavage, moves to the plasma membrane where it strongly binds to inner leaflet lipids, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate (PubMed:28459430). Mediates secondary necrosis downstream of the mitochondrial apoptotic pathway and CASP3 activation as well as in response to viral agents (PubMed:28045099). Exhibits bactericidal activity (PubMed:27281216). Hearing impairment is a heterogeneous condition with over 40 loci described. The protein encoded by this gene is expressed in fetal cochlea, however, its function is not known. Nonsy ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342947
  • ENSP00000339587
  • ENSG00000105928
  • ENST00000409775
  • ENSP00000386670
  • ENST00000409970
  • ENSP00000387119
  • ENST00000419307
  • ENSP00000401332
  • ENST00000645220
  • ENSP00000494186

Symbol
  • DFNA5
  • ICERE1
  • DFNA5
  • ICERE-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.93   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 191   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.93   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (71)
EPHA1
Tchem
Family:  Kinase
Novelty:  0.00136672
p_int:  0.999979601
p_ni:  0.000020399
Data Source:  BioPlex
SIGLECL1
Tdark
p_int:  0.999926481
p_ni:  0.000073519
Data Source:  BioPlex
SCN2B
Tbio
Family:  IC
Novelty:  0.03773629
p_int:  0.996849733
p_ni:  0.003123788
p_wrong:  0.000026479
Data Source:  BioPlex
C16orf58
Tdark
Novelty:  0.34461652
p_int:  0.994659614
p_ni:  0.005340362
p_wrong:  2.4e-8
Data Source:  BioPlex
PLEC
Tbio
Novelty:  0.00223244
p_int:  0.994392417
p_ni:  0.005607583
Score:  0.167
Data Source:  BioPlex,STRINGDB
MUL1
Tbio
Family:  Enzyme
Novelty:  0.00841786
p_int:  0.990596442
p_ni:  0.009403556
p_wrong:  1e-9
Score:  0.181
Data Source:  BioPlex,STRINGDB
ZSCAN29
Tdark
Family:  TF
Novelty:  1.70466621
p_int:  0.93191319
p_ni:  0.067614418
p_wrong:  0.000472393
Score:  0.189
Data Source:  BioPlex,STRINGDB
SLC27A2
Tbio
Family:  Transporter
Novelty:  0.01436035
p_int:  0.927130456
p_ni:  0.072869544
Data Source:  BioPlex
GPAT4
Tbio
Family:  Enzyme
Novelty:  0.03409111
p_int:  0.925531832
p_ni:  0.074468168
Score:  0.297
Data Source:  BioPlex,STRINGDB
TPST2
Tbio
Family:  Enzyme
Novelty:  0.02551048
p_int:  0.873450591
p_ni:  0.126387245
p_wrong:  0.000162164
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
2
2
72.8
3
3
1
1.1
61.8
self reported educational attainment
2
2
2
60.1
wellbeing measurement
3
2
3
57.1
2
2
1
1
52
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
72.8
1
1.1
61.8
self reported educational attainment
2
60.1
wellbeing measurement
3
57.1
1
1
52
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
gasdermin E
VGNC:9066
463295
Macaque
gasdermin E
703441
Mouse
MGI:1889850
54722
Dog
gasdermin E
VGNC:39911
611223
Horse
gasdermin E
VGNC:17143
100033992
Species
Name
OMA
EggNOG
Inparanoid
Chimp
gasdermin E
Macaque
gasdermin E
Mouse
Dog
gasdermin E
Horse
gasdermin E
Publication Statistics
PubMed Score 118.93
PubMed score by year
PubTator Score 42.44
PubTator score by year
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Related Publications
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PMID
Year
Title