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Tbio
PPL
Periplakin

Protein Summary
Description
Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling. The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345988
  • ENSP00000340510
  • ENSG00000118898

Symbol
  • KIAA0568
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.84
PubMedID
0.82
disease perturbation
0.74
cellular component
0.66
interacting protein
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.68   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 181   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.68   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
1
1
63.1
velopharyngeal dysfunction
1
1
1
57.5
waist-hip ratio
1
1
1
57.1
diastolic blood pressure
1
1
1
34.8
body height
1
1
1
11.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
63.1
velopharyngeal dysfunction
1
57.5
waist-hip ratio
1
57.1
diastolic blood pressure
1
34.8
body height
1
11.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1194898
19041
Rat
RGD:1305511
302934
Dog
periplakin
VGNC:44861
490021
Horse
periplakin
VGNC:21739
100069951
Cow
periplakin
VGNC:33208
522886
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
periplakin
Horse
periplakin
Cow
periplakin
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O60437-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Butyrophilin (BTN) family interactions
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Butyrophilin (BTN) family interactions
Developmental Biology
Formation of the cornified envelope
Immune System
Protein-Protein Interactions (150)
1 – 10 of 150
CLMN
Tbio
Novelty: 0.0822701
p_int: 0.999999784
p_ni: 1.85e-7
p_wrong: 3.1e-8
Data Source: BioPlex
DDX19B
Tbio
Family: Enzyme
Novelty: 0.0504568
p_int: 0.999986178
p_ni: 0.000013822
Data Source: BioPlex
FCF1
Tdark
Novelty: 0.04202976
p_int: 0.999982659
p_ni: 0.000017341
Data Source: BioPlex
ITPRID2
Tbio
Novelty: 0.07923791
p_int: 0.99997921
p_ni: 0.00002079
Data Source: BioPlex
CDK15
Tchem
Family: Kinase
Novelty: 0.3870338
p_int: 0.999956545
p_ni: 0.000043455
Score: 0.164
Data Source: BioPlex,STRINGDB
TBC1D22B
Tbio
Novelty: 0.49852962
p_int: 0.999952137
p_ni: 0.000047863
Data Source: BioPlex
HERC2
Tbio
Family: Enzyme
Novelty: 0.06552683
p_int: 0.999949234
p_ni: 0.000050766
Data Source: BioPlex
NEURL4
Tdark
Novelty: 0.20430708
p_int: 0.999939543
p_ni: 0.000060444
p_wrong: 1.4e-8
Data Source: BioPlex
HSF2
Tbio
Family: TF
Novelty: 0.06458223
p_int: 0.999804909
p_ni: 0.000195091
Data Source: BioPlex
ZSCAN20
Tdark
Family: TF
Novelty: 0.37441538
p_int: 0.999644272
p_ni: 0.000355728
Data Source: BioPlex
Publication Statistics
PubMed Score  140.68

PubMed score by year
PubTator Score  44.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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