Protein Summary
Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling. The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. [provided by RefSeq, Jul 2008]
- ENST00000345988
- ENSP00000340510
- ENSG00000118898
- KIAA0568
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.84 | ||
PubMedID | 0.82 | ||
disease perturbation | 0.74 | ||
cellular component | 0.66 | ||
interacting protein | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 142.43 (req: < 5)
Gene RIFs: 21 (req: <= 3)
Antibodies: 181 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 142.43 (req: >= 5)
Gene RIFs: 21 (req: > 3)
Antibodies: 181 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (150)
DDX19B
Family: Enzyme
Novelty: 0.0504568
p_int: 0.999986178
p_ni: 0.000013822
Data Source: BioPlex
CDK15
Family: Kinase
Novelty: 0.3870338
p_int: 0.999956545
p_ni: 0.000043455
Score: 0.164
Data Source: BioPlex,STRINGDB
HERC2
Family: Enzyme
Novelty: 0.06552683
p_int: 0.999949234
p_ni: 0.000050766
Data Source: BioPlex
NEURL4
Novelty: 0.20430708
p_int: 0.999939543
p_ni: 0.000060444
p_wrong: 1.4e-8
Data Source: BioPlex
ZSCAN20
Family: TF
Novelty: 0.37441538
p_int: 0.999644272
p_ni: 0.000355728
Data Source: BioPlex
Nearest Tclin Targets
Pathways (6)
Reactome (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Butyrophilin (BTN) family interactions | ||||
Reactome | Developmental Biology | ||||
Reactome | Formation of the cornified envelope | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Butyrophilin (BTN) family interactions | ||||
Developmental Biology | ||||
Formation of the cornified envelope | ||||
Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (3)
Components (9)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 3 | 3 | 4 | 96.6 | |||||
body mass index | 2 | 2 | 2 | 72.8 | |||||
waist-hip ratio | 2 | 2 | 2 | 49.2 | |||||
BMI-adjusted waist circumference | 1 | 2 | 2 | 42.2 | |||||
diastolic blood pressure | 1 | 1 | 1 | 40.7 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean platelet volume | 4 | 96.6 | |||||
body mass index | 2 | 72.8 | |||||
waist-hip ratio | 2 | 49.2 | |||||
BMI-adjusted waist circumference | 2 | 42.2 | |||||
diastolic blood pressure | 1 | 40.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:1194898 | 19041 | ||||||
Rat | RGD:1305511 | 302934 | ||||||
Dog | periplakin | VGNC:44861 | 490021 | |||||
Horse | periplakin | VGNC:21739 | 100069951 | |||||
Cow | periplakin | VGNC:33208 | 522886 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | periplakin | |||||
Horse | periplakin | |||||
Cow | periplakin | |||||
Publication Statistics
PubMed Score 142.43
PubMed score by year
PubTator Score 44.58
PubTator score by year
Related Publications
Text Mined References (42)
GeneRif Annotations (21)
Items per page:
0 of 0
PMID | Year | Title |
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