Tbio PPL Periplakin

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Intermediate Filament / Intermediate Filament Binding Protein / Periplakin

DTO Classes

Protein / Cellular Structure / Intermediate Filament / Intermediate Filament Binding Protein / Periplakin

Protein Summary

Description

Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling. The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O60437
• O60314
• O60454
• Q14C98

Gene Name

• PPL

Ensembl ID

• ENST00000345988
• ENSP00000340510
• ENSG00000118898

Symbol

• KIAA0568

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.84
PubMedID	0.82
disease perturbation	0.74
cellular component	0.66
interacting protein	0.66

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.68   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 181   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.68   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
C-reactive protein measurement	EFO_0004458	1	1	1		63.1
velopharyngeal dysfunction	EFO_0009336	1	1	1		57.5
waist-hip ratio	EFO_0004343	1	1	1		57.1
diastolic blood pressure	EFO_0006336	1	1	1		34.8
body height	EFO_0004339	1	1	1		11.3

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
C-reactive protein measurement	EFO_0004458	1		63.1
velopharyngeal dysfunction	EFO_0009336	1		57.5
waist-hip ratio	EFO_0004343	1		57.1
diastolic blood pressure	EFO_0006336	1		34.8
body height	EFO_0004339	1		11.3

Reset Zoom  Beta Count   Odds Ratio

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	periplakin	MGI:1194898	19041
Rat	periplakin	RGD:1305511	302934
Dog	periplakin	VGNC:44861	490021
Horse	periplakin	VGNC:21739	100069951
Cow	periplakin	VGNC:33208	522886

Species	Name	OMA	EggNOG	Inparanoid
Mouse	periplakin
Rat	periplakin
Dog	periplakin
Horse	periplakin
Cow	periplakin

Protein Structure (1 Structure, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O60437-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (6)

Reactome (6)

Adaptive Immune System (R-HSA-1280218)

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Find Similar Targets

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Butyrophilin (BTN) family interactions	12 targets	R-HSA-8851680
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	Formation of the cornified envelope	75 targets	R-HSA-6809371
Reactome	Immune System	2246 targets	R-HSA-168256

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218
Butyrophilin (BTN) family interactions	12 targets	R-HSA-8851680
Developmental Biology	1055 targets	R-HSA-1266738
Formation of the cornified envelope	75 targets	R-HSA-6809371
Immune System	2246 targets	R-HSA-168256

Gene Ontology Terms (16)

Functions (3)

Components (9)

Processes (4)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
cadherin binding	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
structural molecule activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
structural constituent of cytoskeleton	Traceable Author Statement (TAS)	ProtInc

Protein-Protein Interactions (150)

Explore Interacting Targets

1 – 10 of 150

• See Interactions on String-DB

CLMN

Tbio

Novelty: 0.0822701

p_int: 0.999999784

p_ni: 1.85e-7

p_wrong: 3.1e-8

Data Source: BioPlex

DDX19B

Tbio

Family: Enzyme

Novelty: 0.0504568

p_int: 0.999986178

p_ni: 0.000013822

Data Source: BioPlex

FCF1

Tdark

Novelty: 0.04202976

p_int: 0.999982659

p_ni: 0.000017341

Data Source: BioPlex

ITPRID2

Tbio

Novelty: 0.07923791

p_int: 0.99997921

p_ni: 0.00002079

Data Source: BioPlex

CDK15

Tchem

Family: Kinase

Novelty: 0.3870338

p_int: 0.999956545

p_ni: 0.000043455

Score: 0.164

Data Source: BioPlex,STRINGDB

TBC1D22B

Tbio

Novelty: 0.49852962

p_int: 0.999952137

p_ni: 0.000047863

Data Source: BioPlex

HERC2

Tbio

Family: Enzyme

Novelty: 0.06552683

p_int: 0.999949234

p_ni: 0.000050766

Data Source: BioPlex

NEURL4

Tdark

Novelty: 0.20430708

p_int: 0.999939543

p_ni: 0.000060444

p_wrong: 1.4e-8

Data Source: BioPlex

HSF2

Tbio

Family: TF

Novelty: 0.06458223

p_int: 0.999804909

p_ni: 0.000195091

Data Source: BioPlex

ZSCAN20

Tdark

Family: TF

Novelty: 0.37441538

p_int: 0.999644272

p_ni: 0.000355728

Data Source: BioPlex

Publication Statistics

PubMed Score  140.68

PubMed score by year

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PubTator Score  44.58

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Find similar targets by:

UniProt Keyword Find Similar Targets

3D-structure
Cell junction
Cell membrane
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
Keratinization
Membrane
Mitochondrion

GWAS Trait Find Similar Targets

body height
C-reactive protein measurement
diastolic blood pressure
velopharyngeal dysfunction
waist-hip ratio

MGI Phenotype Find Similar Targets

immune system phenotype
integument phenotype
renal/urinary system phenotype