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Tdark
ATP8B3
Phospholipid-transporting ATPase IK

Protein Summary
Description
P4-ATPase flippase which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. May be responsible for the maintenance of asymmetric distribution of phosphatidylserine (PS) in spermatozoa membranes. Involved in acrosome reactions and binding of spermatozoa to zona pellucida. The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to the other. This gene encodes member 3 of phospholipid-transporting ATPase 8B; other members of this protein family are located on chromosomes 1, 15 and 18. Alternatively sp ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310127
  • ENSP00000311336
  • ENSG00000130270
  • ENST00000525591
  • ENSP00000437115

Symbol
  • ATP1K
  • FOS37502_2
  • ATPIK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
metabolite
0.98
protein domain
0.92
virus perturbation
0.85
histone modification site profile
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.31   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 51   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.31   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (26)
TMEM30A
Tbio
Novelty:  0.05115559
Score:  0.769
Data Source:  STRINGDB
TMEM30CP
Tdark
Novelty:  0.4661526
Score:  0.721
Data Source:  STRINGDB
AADAC
Tchem
Family:  Enzyme
Novelty:  0.02735072
Score:  0.707
Data Source:  STRINGDB
TMEM30B
Tbio
Novelty:  0.26735006
Score:  0.681
Data Source:  STRINGDB
SLC35F1
Tdark
Family:  Transporter
Novelty:  0.34046601
Score:  0.672
Data Source:  STRINGDB
SFT2D3
Tdark
Novelty:  31.35862045
Score:  0.626
Data Source:  STRINGDB
FDXACB1
Tdark
Novelty:  67
Score:  0.543
Data Source:  STRINGDB
ARL1
Tbio
Family:  Enzyme
Novelty:  0.29930049
Score:  0.541
Data Source:  STRINGDB
TCTE3
Tdark
Novelty:  0.15747856
Score:  0.539
Data Source:  STRINGDB
TEX15
Tbio
Novelty:  0.08059572
Score:  0.52
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Ion transport by P-type ATPases
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Ion transport by P-type ATPases
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
2
2
86.7
mean reticulocyte volume
1
2
2
86.4
body mass index
4
3
4
83.8
mean corpuscular hemoglobin concentration
1
1
1
76.5
reticulocyte measurement
3
1
3
68.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
2
86.7
mean reticulocyte volume
2
86.4
body mass index
4
83.8
mean corpuscular hemoglobin concentration
1
76.5
reticulocyte measurement
3
68.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1914581
67331
Rat
RGD:1307622
299616
Dog
ATPase phospholipid transporting 8B3
VGNC:54575
612245
Opossum
ATPase phospholipid transporting 8B3
100018023
Chicken
ATPase phospholipid transporting 8B3
CGNC:736
428328
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
ATPase phospholipid transporting 8B3
Opossum
ATPase phospholipid transporting 8B3
Chicken
ATPase phospholipid transporting 8B3
Publication Statistics
PubMed Score 2.31
PubMed score by year
PubTator Score 1.48
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title