You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NOBOX
Homeobox protein NOBOX

Protein Summary
Description
Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences 5'-TAATTG-3', 5'-TAGTTG-3' and 5'-TAATTA-3'. This homeobox gene encodes a transcription factor that is thought to play a role in oogenesis. In mice, it is essential for folliculogenesis and regulation of oocyte-specific genes. Defects in this gene result in premature ovarian failure type 5.[provided by RefSeq, May 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000467773
  • ENSP00000419457
  • ENSG00000106410
  • ENST00000483238
  • ENSP00000419565

Symbol
  • OG2
  • OG-2
  • OG2X
  • POF5
  • TCAG_12042
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.76
tissue
0.67
biological process
0.63
cell line
0.54
gene perturbation
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.36   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.36   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (55)
FIGLA
Tbio
Family:  TF
Novelty:  0.02544697
Score:  0.881
Data Source:  STRINGDB
GDF9
Tbio
Novelty:  0.00258351
Score:  0.832
Data Source:  STRINGDB
LHX8
Tbio
Family:  TF
Novelty:  0.01815234
Score:  0.816
Data Source:  STRINGDB
BMP15
Tbio
Novelty:  0.00364888
Score:  0.758
Data Source:  STRINGDB
ZP3
Tbio
Novelty:  0.00140352
Score:  0.752
Data Source:  STRINGDB
SOHLH1
Tbio
Family:  TF
Novelty:  0.04218087
Score:  0.726
Data Source:  STRINGDB
SOHLH2
Tbio
Family:  TF
Novelty:  0.03594754
Score:  0.708
Data Source:  STRINGDB
FOXL2
Tbio
Family:  TF
Novelty:  0.00224046
Score:  0.702
Data Source:  STRINGDB
ZP2
Tbio
Novelty:  0.00310166
Score:  0.675
Data Source:  STRINGDB
YBX2
Tbio
Family:  TF
Novelty:  0.01540247
Score:  0.653
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1
1
1.1
52
1
1
1
52
1
1
1
52
diet measurement
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
52
1
52
1
52
diet measurement
1
14.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NOBOX oogenesis homeobox
VGNC:4443
472575
Mouse
MGI:108011
18291
Rat
RGD:1563929
502759
Dog
NOBOX oogenesis homeobox
VGNC:51816
482717
Horse
NOBOX oogenesis homeobox
VGNC:20791
100058413
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NOBOX oogenesis homeobox
Mouse
Rat
Dog
NOBOX oogenesis homeobox
Horse
NOBOX oogenesis homeobox
Publication Statistics
PubMed Score 88.36
PubMed score by year
PubTator Score 32.35
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title