You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
GRIN3B
Glutamate receptor ionotropic, NMDA 3B

Protein Summary
Description
NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. The protein encoded by this gene is a subunit of an N-methyl-D-aspartate (NMDA) receptor. The encoded protein is found primarily in motor neurons, where it forms a heterotetramer with GRIN1 to create an excitatory glycine receptor. Variations in this gene have been proposed to be linked to schizophrenia. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000234389
  • ENSP00000234389
  • ENSG00000116032

Symbol
  • NR3B
  • GluN3B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
drug
0.72
gene perturbation
0.68
cell line
0.67
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.03   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.03   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Pathways (107)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Assembly and cell surface presentation of NMDA receptors
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Reactome
Transmission across Chemical Synapses
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Assembly and cell surface presentation of NMDA receptors
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Transmission across Chemical Synapses
Gene Ontology Terms (14)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (84)
1 – 10 of 84
DLG4
Tchem
Novelty: 0.00079421
Score: 0.935
Data Source: STRINGDB
GRIN1
Tclin
Family: IC
Novelty: 0.00132693
Score: 0.915
Data Source: Reactome,STRINGDB
GRIN2A
Tclin
Family: IC
Novelty: 0.00075253
Score: 0.871
Data Source: Reactome,STRINGDB
CACNG2
Tbio
Family: IC
Novelty: 0.01171137
Score: 0.827
Data Source: STRINGDB
GRIA4
Tclin
Family: IC
Novelty: 0.00363124
Score: 0.812
Data Source: STRINGDB
PRKACA
Tchem
Family: Kinase
Novelty: 0.05996003
Score: 0.809
Data Source: STRINGDB
GRIA1
Tclin
Family: IC
Novelty: 0.00063312
Score: 0.807
Data Source: STRINGDB
GRIN2D
Tclin
Family: IC
Novelty: 0.00730668
Score: 0.805
Data Source: STRINGDB
GRIA3
Tclin
Family: IC
Novelty: 0.00921177
Score: 0.802
Data Source: STRINGDB
GRIA2
Tclin
Family: IC
Novelty: 0.00187801
Score: 0.802
Data Source: STRINGDB
Publication Statistics
PubMed Score  26.03

PubMed score by year
PubTator Score  22.65

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: