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Tbio
CACNG3
Voltage-dependent calcium channel gamma-3 subunit

Protein Summary
Description
Regulates the trafficking to the somatodendritic compartment and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family. This gene is a susceptibility locus for childhood absence epilepsy. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000005284
  • ENSP00000005284
  • ENSG00000006116
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.76
gene perturbation
0.55
cell line
0.53
cellular component
0.53
metabolite
0.45


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.18   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 217   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.18   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 217   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
64
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
64
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcium voltage-gated channel auxiliary subunit gamma 3
VGNC:13671
746707
Macaque
calcium voltage-gated channel auxiliary subunit gamma 3
701324
Mouse
MGI:1859165
54376
Rat
RGD:628803
140724
Dog
calcium voltage-gated channel auxiliary subunit gamma 3
VGNC:38649
489967
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcium voltage-gated channel auxiliary subunit gamma 3
Macaque
calcium voltage-gated channel auxiliary subunit gamma 3
Mouse
Rat
Dog
calcium voltage-gated channel auxiliary subunit gamma 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O60359-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (24)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Developmental Biology
Reactome
Glutamate binding, activation of AMPA receptors and synaptic plasticity
Reactome
LGI-ADAM interactions
Reactome
Muscle contraction
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Developmental Biology
Glutamate binding, activation of AMPA receptors and synaptic plasticity
LGI-ADAM interactions
Muscle contraction
Protein-Protein Interactions (180)
1 – 10 of 180
POTEF
Tbio
Novelty: 0.00191599
p_int: 0.996926827
p_ni: 0.003073172
Score: 0.208
Data Source: BioPlex,STRINGDB
PLK1
Tchem
Family: Kinase
Novelty: 0.00062799
p_int: 0.985430354
p_ni: 0.014569646
Score: 0.268
Data Source: BioPlex,STRINGDB
CACNB1
Tbio
Family: IC
Novelty: 0.06568749
Score: 0.972
Data Source: STRINGDB
CACNA2D1
Tclin
Family: IC
Novelty: 0.01744541
Score: 0.964
Data Source: STRINGDB
CACNB3
Tbio
Family: IC
Novelty: 0.04007679
Score: 0.955
Data Source: STRINGDB
CAMK2A
Tchem
Family: Kinase
Novelty: 0.00534906
Score: 0.953
Data Source: STRINGDB
CACNA1D
Tclin
Family: IC
Novelty: 0.00314752
Score: 0.949
Data Source: STRINGDB
CACNB4
Tbio
Family: IC
Novelty: 0.01564026
Score: 0.945
Data Source: STRINGDB
GRIA1
Tclin
Family: IC
Novelty: 0.0005008
Score: 0.944
Data Source: STRINGDB
CACNG1
Tbio
Family: IC
Novelty: 0.11899252
Score: 0.944
Data Source: STRINGDB
Publication Statistics
PubMed Score  3.18

PubMed score by year
PubTator Score  3.24

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer