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Tbio
FZD6
Frizzled-6

Protein Summary
Description
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358755
  • ENSP00000351605
  • ENSG00000164930
  • ENST00000522566
  • ENSP00000429055
  • ENST00000523739
  • ENSP00000429528

Symbol
  • FZ6
  • FZ-6
  • HFZ6
  • NDNC10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
PubMedID
0.83
protein domain
0.73
ligand (protein)
0.68
tissue sample
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.47   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 317   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.47   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 317   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (129)
NKAIN1
Tdark
Family:  Enzyme
Novelty:  0.52190272
p_int:  0.999965288
p_ni:  0.000034559
p_wrong:  1.53e-7
Data Source:  BioPlex
ZNRF4
Tbio
Novelty:  0.16505328
p_int:  0.999938907
p_ni:  0.000061066
p_wrong:  2.6e-8
Data Source:  BioPlex
GP9
Tbio
Novelty:  0.00365769
p_int:  0.999888777
p_ni:  0.000104114
p_wrong:  0.000007109
Data Source:  BioPlex
LRRC55
Tbio
Family:  IC
Novelty:  0.25121277
p_int:  0.998916588
p_ni:  0.000949704
p_wrong:  0.000133708
Data Source:  BioPlex
SYNE4
Tbio
Novelty:  0.0739848
p_int:  0.99745067
p_ni:  0.000074077
p_wrong:  0.002475254
Data Source:  BioPlex
VNN2
Tbio
Novelty:  0.02286648
p_int:  0.996916929
p_ni:  0.000136585
p_wrong:  0.002946486
Data Source:  BioPlex
TMPRSS12
Tdark
Family:  Enzyme
Novelty:  0.38051198
p_int:  0.926249368
p_ni:  0.006699953
p_wrong:  0.067050679
Score:  0.189
Data Source:  BioPlex,STRINGDB
GABRE
Tclin
Family:  IC
Novelty:  0.03814541
p_int:  0.878401519
p_ni:  0.002053628
p_wrong:  0.119544853
Score:  0.171
Data Source:  BioPlex,STRINGDB
ADGRG5
Tdark
Family:  GPCR
Novelty:  0.26575982
p_int:  0.857865687
p_ni:  0.001067888
p_wrong:  0.141066425
Score:  0.274
Data Source:  BioPlex,STRINGDB
RAMP1
Tclin
Novelty:  0.00831253
p_int:  0.780645922
p_ni:  0.000650149
p_wrong:  0.218703929
Data Source:  BioPlex
Nearest Tclin Targets (9)
Explore Nearest Tclin Targets
1 – 5 of 7
MAP2K1
Tclin
Family:  Kinase
KEGG Distance:  5
Common Pathways:  10
more:  6 more common pathways
EGFR
Tclin
Family:  Kinase
KEGG Distance:  5
Common Pathways:  7
more:  3 more common pathways
BRAF
Tclin
Family:  Kinase
KEGG Distance:  5
Common Pathways:  7
more:  3 more common pathways
MAP2K2
Tclin
Family:  Kinase
KEGG Distance:  5
Common Pathways:  10
more:  6 more common pathways
Pathways (68)
Beta-catenin independent WNT signaling (R-HSA-3858494)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-catenin independent WNT signaling
Reactome
Ca2+ pathway
Reactome
Class B/2 (Secretin family receptors)
Reactome
Disease
Reactome
Diseases of signal transduction
Name
Explore in Pharos
Explore in Source
Beta-catenin independent WNT signaling
Ca2+ pathway
Class B/2 (Secretin family receptors)
Disease
Diseases of signal transduction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
1
2
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
frizzled class receptor 6
VGNC:869
464327
Macaque
frizzled class receptor 6
694625
Mouse
MGI:108474
14368
Rat
RGD:628816
282581
Dog
frizzled class receptor 6
VGNC:41034
403610
Species
Name
OMA
EggNOG
Inparanoid
Chimp
frizzled class receptor 6
Macaque
frizzled class receptor 6
Mouse
Rat
Dog
frizzled class receptor 6
Publication Statistics
PubMed Score 82.47
PubMed score by year
PubTator Score 41.15
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title