PHLPP1
PH domain leucine-rich repeat-containing protein phosphatase 1
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
pathway | 0.93 | ||
kinase perturbation | 0.88 | ||
disease perturbation | 0.87 | ||
transcription factor binding site profile | 0.86 | ||
virus perturbation | 0.72 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Intracellular signaling by second messengers | ||||
Reactome | Negative regulation of the PI3K/AKT network | ||||
Reactome | PIP3 activates AKT signaling | ||||
Reactome | Signal Transduction | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Intracellular signaling by second messengers | ||||
Negative regulation of the PI3K/AKT network | ||||
PIP3 activates AKT signaling | ||||
Signal Transduction | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
platelet crit | 1 | 1 | 1 | 55.2 | |||||
inflammatory biomarker measurement | 1 | 1 | 0 | 46.6 | 7.6 | ||||
body mass index | 1 | 1 | 1 | 7.1 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
platelet crit | 1 | 55.2 | |||||
inflammatory biomarker measurement | 0 | 46.6 | 7.6 | ||||
body mass index | 1 | 7.1 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | PH domain and leucine rich repeat protein phosphatase 1 | VGNC:13275 | 468563 | |||||
Macaque | PH domain and leucine rich repeat protein phosphatase 1 | 705882 | ||||||
Mouse | MGI:2138327 | 98432 | ||||||
Rat | RGD:621308 | 59265 | ||||||
Dog | PH domain and leucine rich repeat protein phosphatase 1 | VGNC:44504 | 476179 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | PH domain and leucine rich repeat protein phosphatase 1 | |||||
Macaque | PH domain and leucine rich repeat protein phosphatase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | PH domain and leucine rich repeat protein phosphatase 1 | |||||
PMID | Year | Title |
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