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Tbio
TBC1D4
TBC1 domain family member 4

Protein Summary
Description
May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. This gene is a member of the Tre-2/BUB2/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein, and contains two phopshotyrosine-binding domains (PTB1 and PTB2), a calmodulin-binding domain (CBD), a Rab-GTPase domain, and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin, this protein is phosphorylated, d ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377625
  • ENSP00000366852
  • ENSG00000136111
  • ENST00000377636
  • ENSP00000366863
  • ENST00000431480
  • ENSP00000395986

Symbol
  • AS160
  • KIAA0603
  • AS160
  • NIDDM5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.81
kinase
0.75
drug perturbation
0.71
PubMedID
0.7
microRNA
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.21   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 426   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.21   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 426   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (100)
FAM9B
Tdark
Novelty:  0.39508009
p_int:  0.998626302
p_ni:  0.001373698
Data Source:  BioPlex
CTDSP2
Tbio
Family:  Enzyme
Novelty:  0.01033594
p_int:  0.991316007
p_ni:  0.008683993
Score:  0.16
Data Source:  BioPlex,STRINGDB
APBB2
Tbio
Novelty:  0.06546724
p_int:  0.985819765
p_ni:  0.014180235
Score:  0.158
Data Source:  BioPlex,STRINGDB
CCNA2
Tchem
Novelty:  0.00049887
p_int:  0.978555474
p_ni:  0.021444526
Data Source:  BioPlex
TMOD3
Tbio
Novelty:  0.04744699
p_int:  0.97741766
p_ni:  0.02258234
Score:  0.307
Data Source:  BioPlex,STRINGDB
NRBP1
Tbio
Family:  Kinase
Novelty:  0.05902656
p_int:  0.976477316
p_ni:  0.023522684
Data Source:  BioPlex
EIF4E3
Tbio
Novelty:  0.07055626
p_int:  0.974115736
p_ni:  0.025884264
Score:  0.539
Data Source:  BioPlex,STRINGDB
TP53INP1
Tbio
Novelty:  0.00407247
p_int:  0.968203948
p_ni:  0.031796052
Score:  0.188
Data Source:  BioPlex,STRINGDB
MYF6
Tbio
Family:  TF
Novelty:  0.00509046
p_int:  0.956321185
p_ni:  0.043678815
Score:  0.186
Data Source:  BioPlex,STRINGDB
IQCF1
Tdark
Novelty:  0.78525464
p_int:  0.945779407
p_ni:  0.054220593
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (199)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
3
3
3
92.2
red blood cell density measurement
2
2
2
88.7
mean corpuscular hemoglobin concentration
2
2
2
87.6
mean platelet volume
3
3
3
81.6
1
1
0
4.4
62.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
3
92.2
red blood cell density measurement
2
88.7
mean corpuscular hemoglobin concentration
2
87.6
mean platelet volume
3
81.6
0
4.4
62.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TBC1 domain family member 4
VGNC:5117
467286
Macaque
TBC1 domain family member 4
696915
Mouse
MGI:2429660
210789
Rat
RGD:1561609
306117
Dog
TBC1 domain family member 4
VGNC:47149
485494
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TBC1 domain family member 4
Macaque
TBC1 domain family member 4
Mouse
Rat
Dog
TBC1 domain family member 4
Publication Statistics
PubMed Score 174.21
PubMed score by year
PubTator Score 99.22
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title