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Tchem
KDM1A
Lysine-specific histone demethylase 1A

Protein Summary
Description
Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356634
  • ENSP00000349049
  • ENSG00000004487
  • ENST00000400181
  • ENSP00000383042

Symbol
  • AOF2
  • KDM1
  • KIAA0601
  • LSD1
  • AOF2
  • CPRF
  • KDM1
  • LSD1
  • BHC110
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
protein complex
1
disease perturbation
0.97
transcription factor binding site profile
0.94


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 908.48   (req: < 5)
Gene RIFs: 209   (req: <= 3)
Antibodies: 619   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 908.48   (req: >= 5)
Gene RIFs: 209   (req: > 3)
Antibodies: 619   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 49
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 543
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (543)
1 – 10 of 543
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
1
3
3
74.5
body height
2
2
2
73.7
body mass index
2
2
2
67
serum gamma-glutamyl transferase measurement
1
1
1
59.9
mean corpuscular volume
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
3
74.5
body height
2
73.7
body mass index
2
67
serum gamma-glutamyl transferase measurement
1
59.9
mean corpuscular volume
1
31.4
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lysine demethylase 1A
VGNC:8065
456614
Macaque
lysine demethylase 1A
718609
Mouse
MGI:1196256
99982
Rat
RGD:1562975
500569
Dog
lysine demethylase 1A
VGNC:42318
478193
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lysine demethylase 1A
Macaque
lysine demethylase 1A
Mouse
Rat
Dog
lysine demethylase 1A
Protein Structure (58 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O60341-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 58
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (31)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (R-HSA-5625886)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
ESR-mediated signaling
Reactome
Estrogen-dependent gene expression
Name
Explore in Pharos
Explore in Source
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Chromatin modifying enzymes
Chromatin organization
ESR-mediated signaling
Estrogen-dependent gene expression
Gene Ontology Terms (56)
Items per page:
10
1 – 10 of 18
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Protein-Protein Interactions (376)
1 – 10 of 376
HMG20A
Tbio
Family:  TF
Novelty:  0.11994252
p_int:  0.995896022
p_ni:  0.004103978
Score:  0.668
Data Source:  BioPlex,STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  0.99350838
p_ni:  0.00649162
Score:  0.99
Data Source:  BioPlex,Reactome,STRINGDB
HMG20B
Tbio
Family:  TF
Novelty:  0.05983143
p_int:  0.972797653
p_ni:  0.027202347
Score:  0.991
Data Source:  BioPlex,STRINGDB
ZSCAN5A
Tdark
Family:  TF
Novelty:  2.15267128
p_int:  0.855734899
p_ni:  0.144265101
Score:  0.237
Data Source:  BioPlex,STRINGDB
ECE2
Tchem
Family:  Enzyme
Novelty:  0.03234301
p_int:  0.849658959
p_ni:  0.150341041
Score:  0.232
Data Source:  BioPlex,STRINGDB
CRYAA
Tchem
Novelty:  0.01914081
p_int:  0.841477031
p_ni:  0.158522969
Data Source:  BioPlex
CTBP1
Tbio
Novelty:  0.00243818
p_int:  0.82851488
p_ni:  0.17148512
Score:  0.976
Data Source:  BioPlex,STRINGDB
ARRDC1
Tbio
Novelty:  0.10481621
p_int:  0.792626944
p_ni:  0.207373056
Data Source:  BioPlex
TMEM266
Tdark
Novelty:  0.26313861
p_int:  0.778271764
p_ni:  0.221728236
Score:  0.188
Data Source:  BioPlex,STRINGDB
RCOR1
Tbio
Family:  TF
Novelty:  0.00644648
Score:  0.999
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  908.48

PubMed score by year
PubTator Score  444.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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