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Tchem
KDM1A
Lysine-specific histone demethylase 1A

Protein Summary
Description
Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356634
  • ENSP00000349049
  • ENSG00000004487
  • ENST00000400181
  • ENSP00000383042

Symbol
  • AOF2
  • KDM1
  • KIAA0601
  • LSD1
  • AOF2
  • CPRF
  • KDM1
  • LSD1
  • BHC110
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
protein complex
1
disease perturbation
0.97
transcription factor binding site profile
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1068.12   (req: < 5)
Gene RIFs: 209   (req: <= 3)
Antibodies: 619   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1068.12   (req: >= 5)
Gene RIFs: 209   (req: > 3)
Antibodies: 619   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 49
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 692
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0