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Tbio
KIF1B
Kinesin-like protein KIF1B

Protein Summary
Description
Motor for anterograde transport of mitochondria. Has a microtubule plus end-directed motility. Isoform 2 is required for induction of neuronal apoptosis. This gene encodes a motor protein that transports mitochondria and synaptic vesicle precursors. Mutations in this gene cause Charcot-Marie-Tooth disease, type 2A1. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263934
  • ENSP00000263934
  • ENSG00000054523
  • ENST00000377081
  • ENSP00000366284
  • ENST00000377083
  • ENSP00000366287
  • ENST00000377086
  • ENSP00000366290
  • ENST00000377093
  • ENSP00000366297

Symbol
  • KIAA0591
  • KIAA1448
  • KLP
  • CMT2
  • CMT2A
  • CMT2A1
  • HMSNII
  • NBLST1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
transcription factor perturbation
1
molecular function
0.99
microRNA
0.96
transcription factor binding site profile
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 216.96   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 216.96   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0