KIF1B
Kinesin-like protein KIF1B
Protein Summary
Motor for anterograde transport of mitochondria. Has a microtubule plus end-directed motility. Isoform 2 is required for induction of neuronal apoptosis. This gene encodes a motor protein that transports mitochondria and synaptic vesicle precursors. Mutations in this gene cause Charcot-Marie-Tooth disease, type 2A1. [provided by RefSeq, Jul 2008]
- ENST00000263934
- ENSP00000263934
- ENSG00000054523
- ENST00000377081
- ENSP00000366284
- ENST00000377083
- ENSP00000366287
- ENST00000377086
- ENSP00000366290
- ENST00000377093
- ENSP00000366297
- KIAA0591
- KIAA1448
- KLP
- CMT2
- CMT2A
- CMT2A1
- HMSNII
- NBLST1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
transcription factor perturbation | 1 | ||
molecular function | 0.99 | ||
microRNA | 0.96 | ||
transcription factor binding site profile | 0.94 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 216.96 (req: < 5)
Gene RIFs: 47 (req: <= 3)
Antibodies: 95 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 216.96 (req: >= 5)
Gene RIFs: 47 (req: > 3)
Antibodies: 95 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 23
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0