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Tchem
PIP5K1C
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma

Protein Summary
Description
Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as vesicle mediated transport, cell adhesion, cell polarization and cell migration. Together with PIP5K1A is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle attachment by generating the pool of PtdIns(4,5)P2 that induces controlled actin depolymerization to facilitate Fc-gamma-R clustering. Mediates RAC1-dependent reorganization of actin filaments. Required for synaptic vesicle transport. Controls the plasma membrane p ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335312
  • ENSP00000335333
  • ENSG00000186111
  • ENST00000537021
  • ENSP00000444779
  • ENST00000539785
  • ENSP00000445992
  • ENST00000589578
  • ENSP00000466363

Symbol
  • KIAA0589
  • LCCS3
  • PIP5Kgamma
  • PIP5K-GAMMA
  • PIP5K1-gamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
transcription factor binding site profile
0.75
protein domain
0.73
biological process
0.7
pathway
0.69


Related Tools
Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.5   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 218   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.5   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 218   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL1241674
chemical structure image
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol-4-phosphate 5-kinase type 1 gamma
VGNC:13656
455590
Macaque
phosphatidylinositol-4-phosphate 5-kinase type 1 gamma
721744
Mouse
MGI:1298224
18717
Rat
RGD:1309938
314641
Dog
phosphatidylinositol-4-phosphate 5-kinase type 1 gamma
VGNC:44576
485054
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol-4-phosphate 5-kinase type 1 gamma
Macaque
phosphatidylinositol-4-phosphate 5-kinase type 1 gamma
Mouse
Rat
Dog
phosphatidylinositol-4-phosphate 5-kinase type 1 gamma
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O60331-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (42)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Clathrin-mediated endocytosis
Reactome
Developmental Biology
Reactome
Intracellular signaling by second messengers
Reactome
Membrane Trafficking
Name
Explore in Pharos
Explore in Source
Axon guidance
Clathrin-mediated endocytosis
Developmental Biology
Intracellular signaling by second messengers
Membrane Trafficking
Gene Ontology Terms (23)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (120)
1 – 10 of 120
PIP5K1A
Tbio
Family: Kinase
Novelty: 0.05039085
p_int: 0.999999112
p_ni: 4e-9
p_wrong: 8.85e-7
Score: 0.963
Data Source: BioPlex,STRINGDB
RABGGTB
Tbio
Family: Enzyme
Novelty: 0.06786314
p_int: 0.999995354
p_ni: 1.5e-8
p_wrong: 0.000004631
Score: 0.66
Data Source: BioPlex,STRINGDB
TLN1
Tbio
Novelty: 0.00803981
Score: 0.996
Data Source: Reactome,STRINGDB
ARF6
Tbio
Family: Enzyme
Novelty: 0.00278138
Score: 0.982
Data Source: STRINGDB
PI4KA
Tchem
Family: Kinase
Novelty: 0.01701469
Score: 0.968
Data Source: STRINGDB
PI4KB
Tchem
Family: Kinase
Novelty: 0.00856875
Score: 0.967
Data Source: STRINGDB
TLN2
Tbio
Novelty: 0.0284423
Score: 0.963
Data Source: STRINGDB
PIK3CD
Tclin
Family: Kinase
Novelty: 0.00572779
Score: 0.952
Data Source: STRINGDB
SACM1L
Tbio
Family: Enzyme
Novelty: 0.00499867
Score: 0.942
Data Source: STRINGDB
CDH1
Tbio
Novelty: 0.00010629
Score: 0.94
Data Source: STRINGDB
Publication Statistics
PubMed Score  29.50

PubMed score by year
PubTator Score  13.03

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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