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Tbio
MCM3AP
Germinal-center associated nuclear protein

Protein Summary
Description
Isoform GANP: Essential for the generation of high-affinity B-cells against T-cell-dependent antigens by affecting somatic hypermutation at the IgV-regions. May have stimulation-dependent DNA primase activity that would generate extra RNA primers in very rapidely proliferating cells and would support clonal expansion of differentiating B-cells (By similarity). Involved in the nuclear export of poly(A)-containing mRNAs by acting as a scaffold for the TREX-2 complex. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Isoform MCM3AP: Acetyltransferase targeting MCM3. Inhibits initiation of DNA replication, but not elongation. The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291688
  • ENSP00000291688
  • ENSG00000160294
  • ENST00000397708
  • ENSP00000380820

Symbol
  • GANP
  • KIAA0572
  • MAP80
  • GANP
  • SAC3
  • MAP80
  • PNRIID
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
kinase perturbation
0.81
histone modification site profile
0.8
transcription factor binding site profile
0.75
transcription factor perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.11   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 209   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.11   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 209   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
1
1
53.7
1
1
0
1.2
52
1
1
0
1.3
35
1
1
1
33.1
1
1
0
1.1
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
53.7
0
1.2
52
0
1.3
35
1
33.1
0
1.1
28.1
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
minichromosome maintenance complex component 3 associated protein
VGNC:1137
470113
Macaque
minichromosome maintenance complex component 3 associated protein
721810
Mouse
MGI:1930089
54387
Rat
RGD:1306834
294339
Dog
minichromosome maintenance complex component 3 associated protein
VGNC:43083
480810
Species
Name
OMA
EggNOG
Inparanoid
Chimp
minichromosome maintenance complex component 3 associated protein
Macaque
minichromosome maintenance complex component 3 associated protein
Mouse
Rat
Dog
minichromosome maintenance complex component 3 associated protein
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O60318-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (87)
1 – 10 of 87
CETN1
Tbio
Novelty:  0.01208917
p_int:  0.998381771
p_ni:  0.001618229
Score:  0.839
Data Source:  BioPlex,STRINGDB
IER2
Tbio
Novelty:  0.03864806
p_int:  0.88883507
p_ni:  0.11116493
Score:  0.239
Data Source:  BioPlex,STRINGDB
HPSE2
Tbio
Family:  Enzyme
Novelty:  0.00583615
p_int:  0.880398219
p_ni:  0.119601781
Data Source:  BioPlex
IQCN
Tdark
Novelty:  2.74045479
p_int:  0.775646538
p_ni:  0.224353462
Score:  0.173
Data Source:  BioPlex,STRINGDB
ENY2
Tbio
Novelty:  0.00818283
Score:  0.978
Data Source:  STRINGDB
CETN3
Tbio
Novelty:  0.00705513
Score:  0.976
Data Source:  STRINGDB
MCM3
Tbio
Novelty:  0.00593382
Score:  0.974
Data Source:  STRINGDB
PCID2
Tbio
Novelty:  0.22455574
Score:  0.969
Data Source:  STRINGDB
NXF1
Tbio
Novelty:  0.00642439
Score:  0.95
Data Source:  STRINGDB
THOC2
Tbio
Novelty:  0.02886456
Score:  0.935
Data Source:  STRINGDB
Publication Statistics
PubMed Score  61.11

PubMed score by year
PubTator Score  51.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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