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Tbio
ZEB2
Zinc finger E-box-binding homeobox 2

Protein Summary
Description
Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin. The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000409487
  • ENSP00000386854
  • ENSG00000169554
  • ENST00000539609
  • ENSP00000443792
  • ENST00000558170
  • ENSP00000454157
  • ENST00000627532
  • ENSP00000487174

Symbol
  • KIAA0569
  • SIP1
  • ZFHX1B
  • ZFX1B
  • SIP1
  • SIP-1
  • ZFHX1B
  • HSPC082
  • SMADIP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.97
PubMedID
0.87
biological term
0.85
protein domain
0.85
transcription factor
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 371.8   (req: < 5)
Gene RIFs: 175   (req: <= 3)
Antibodies: 584   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 371.8   (req: >= 5)
Gene RIFs: 175   (req: > 3)
Antibodies: 584   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (32)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (122)
1 – 10 of 122
CTBP1
Tbio
Novelty: 0.00313629
p_int: 0.99999908
p_ni: 3.3e-8
p_wrong: 8.87e-7
Score: 0.712
Data Source: BioPlex,STRINGDB
CDH1
Tbio
Novelty: 0.0001303
Score: 0.938
Data Source: STRINGDB
SMAD3
Tbio
Family: TF
Novelty: 0.00058288
Score: 0.831
Data Source: STRINGDB
TWIST1
Tbio
Family: TF
Novelty: 0.0011524
Score: 0.826
Data Source: STRINGDB
ZEB1
Tbio
Family: TF
Novelty: 0.00096186
Score: 0.825
Data Source: STRINGDB
SMAD5
Tbio
Family: TF
Novelty: 0.00607935
Score: 0.751
Data Source: STRINGDB
SMAD2
Tbio
Family: TF
Novelty: 0.00049143
Score: 0.748
Data Source: STRINGDB
CDH2
Tbio
Novelty: 0.00055399
Score: 0.746
Data Source: STRINGDB
PTEN
Tchem
Family: Enzyme
Novelty: 0.00017995
Score: 0.741
Data Source: STRINGDB
TWIST2
Tbio
Family: TF
Novelty: 0.00595362
Score: 0.738
Data Source: STRINGDB
Publication Statistics
PubMed Score  371.80

PubMed score by year
PubTator Score  342.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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