ZEB2
Zinc finger E-box-binding homeobox 2
Protein Summary
Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin. The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jan 2010]
- ENST00000409487
- ENSP00000386854
- ENSG00000169554
- ENST00000539609
- ENSP00000443792
- ENST00000558170
- ENSP00000454157
- ENST00000627532
- ENSP00000487174
- KIAA0569
- SIP1
- ZFHX1B
- ZFX1B
- SIP1
- SIP-1
- ZFHX1B
- HSPC082
- SMADIP1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.97 | ||
PubMedID | 0.87 | ||
biological term | 0.85 | ||
protein domain | 0.85 | ||
transcription factor | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 650.56 (req: < 5)
Gene RIFs: 270 (req: <= 3)
Antibodies: 584 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 650.56 (req: >= 5)
Gene RIFs: 270 (req: > 3)
Antibodies: 584 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 28
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0