Tchem OPA1 Dynamin-like 120 kDa protein, mitochondrial

Protein Summary

Description

Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission (PubMed:16778770, PubMed:17709429, PubMed:20185555, PubMed:24616225, PubMed:28746876). Coexpression of isoform 1 with shorter alternative products is required for optimal activity in promoting mitochondrial fusion (PubMed:17709429). Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation (PubMed:20185555). The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes (PubMed:20185555). Plays a role in remodeling cristae and the release of cytochrome c during apoptosis (By similarity). Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space (By similarity). Plays a role in mitochondrial genome maintenance (PubMed:20974897, PubMed:18158317). Dynamin-like 120 kDa protein, form S1: Inactive form produced by cleavage at S1 position by OMA1 following stress conditions that induce loss of mitochondrial membrane potential, leading to negative regulation of mitochondrial fusion. Isoforms that contain the alternative exon 4b (present in isoform 4 and isoform 5) are required for mitochondrial genome maintenance, possibly by anchoring the mitochondrial nucleoids to the inner mitochondrial membrane. The protein encoded by this gene is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. The encoded protein localizes to the inner mitochondrial membrane and helps regulate mitochondrial stability and energy output. This protein also sequesters cytochrome c. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. [provided by RefSeq, Aug 2017]

Uniprot Accession IDs

• O60313
• D3DNW4
• E5KLJ5
• E5KLJ6
• E5KLJ7
• E5KLK1
• E5KLK2

Gene Name

• OPA1

Ensembl ID

• ENST00000361150
• ENSP00000354781
• ENSG00000198836
• ENST00000361510
• ENSP00000355324
• ENST00000361828
• ENSP00000354429
• ENST00000361908
• ENSP00000354681
• ENST00000392437
• ENSP00000376232
• ENST00000392438
• ENSP00000376233
• ENST00000646793
• ENSP00000494512

Symbol

• KIAA0567
• NPG
• NTG
• MGM1
• BERHS
• largeG
• MTDPS14

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.96
molecular function	0.95
biological term	0.9
virus perturbation	0.9
disease perturbation	0.87

Protein Classes

PANTHER Classes

Protein / Hydrolase / Dynamin-like 120 Kda Protein, Mitochondrial

Protein / Enzyme Modulator / G-protein / Small Gtpase / Dynamin-like 120 Kda Protein, Mitochondrial

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Dynamin-like 120 Kda Protein, Mitochondrial

DTO Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Dynamin-like 120 Kda Protein, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 639.05   (req: < 5)

Gene RIFs: 237   (req: <= 3)

Antibodies: 270   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 639.05   (req: >= 5)

Gene RIFs: 237   (req: > 3)

Antibodies: 270   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0