Tbio ATP10A Probable phospholipid-transporting ATPase VA

Protein Summary

Description

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. This gene is maternally expressed. It maps within the most common interval of deletion responsible for Angelman syndrome, also known as 'happy puppet syndrome'. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O60312
• Q4G0S9
• Q969I4

Gene Name

• ATP10A

Ensembl ID

• ENST00000356865
• ENSP00000349325
• ENSG00000206190
• ENST00000389967
• ENSP00000374617
• ENST00000619904
• ENSP00000480665

Symbol

• ATP10C
• ATPVA
• ATPVC
• KIAA0566
• ATPVA
• ATPVC
• ATP10C

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
metabolite	0.98
protein domain	0.92
trait	0.86
kinase perturbation	0.81

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Probable Phospholipid-transporting Atpase Va

Protein / Hydrolase / Probable Phospholipid-transporting Atpase Va

DTO Classes

Protein / Transporter / P-type Atpases / Phospholipid-transporting Atpases / Probable Phospholipid-transporting Atpase Va

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.09   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 15   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.09   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 15   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0