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Tbio
ATP10A
Probable phospholipid-transporting ATPase VA

Protein Summary
Description
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. This gene is maternally expressed. It maps within the most common interval of deletion responsible for Angelman syndrome, also known as 'happy puppet syndrome'. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356865
  • ENSP00000349325
  • ENSG00000206190
  • ENST00000389967
  • ENSP00000374617
  • ENST00000619904
  • ENSP00000480665

Symbol
  • ATP10C
  • ATPVA
  • ATPVC
  • KIAA0566
  • ATPVA
  • ATPVC
  • ATP10C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
metabolite
0.98
protein domain
0.92
trait
0.86
kinase perturbation
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.48   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 15   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.48   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 15   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (55)
UBE3A
Tbio
Family:  Enzyme
Novelty:  0.00149368
Score:  0.818
Data Source:  STRINGDB
TUBGCP5
Tbio
Novelty:  0.04863776
Score:  0.799
Data Source:  STRINGDB
MAGEL2
Tbio
Novelty:  0.01419258
Score:  0.734
Data Source:  STRINGDB
SNRPN
Tbio
Novelty:  0.002157
Score:  0.732
Data Source:  STRINGDB
NIPA2
Tbio
Novelty:  0.05451663
Score:  0.722
Data Source:  STRINGDB
MKRN3
Tbio
Family:  Enzyme
Novelty:  0.01192486
Score:  0.706
Data Source:  STRINGDB
TMEM30A
Tbio
Novelty:  0.05115559
Score:  0.69
Data Source:  STRINGDB
NDN
Tbio
Novelty:  0.0045625
Score:  0.687
Data Source:  STRINGDB
GABRB3
Tclin
Family:  IC
Novelty:  0.00485997
Score:  0.677
Data Source:  STRINGDB
CNGA3
Tchem
Family:  IC
Novelty:  0.00818181
Score:  0.673
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (25)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Ion transport by P-type ATPases
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Ion transport by P-type ATPases
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HOMA-B
1
2
0
23.4
41.9
diastolic blood pressure
1
1
1
35
suicide
1
1
1
24.5
balding measurement
1
1
1
2.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HOMA-B
0
23.4
41.9
diastolic blood pressure
1
35
suicide
1
24.5
balding measurement
1
2.2
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase phospholipid transporting 10A (putative)
VGNC:7770
453268
Mouse
MGI:1330809
11982
Rat
RGD:1306150
365266
Dog
ATPase phospholipid transporting 10A (putative)
VGNC:53148
488691
Horse
ATPase phospholipid transporting 10A (putative)
100062211
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase phospholipid transporting 10A (putative)
Mouse
Rat
Dog
ATPase phospholipid transporting 10A (putative)
Horse
ATPase phospholipid transporting 10A (putative)
Publication Statistics
PubMed Score 28.48
PubMed score by year
PubTator Score 12.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title