Tbio AQR RNA helicase aquarius

Protein Summary

Description

Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:25599396, PubMed:28502770, PubMed:28076346). Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis (PubMed:16949364). Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly (PubMed:16949364). May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing (PubMed:16949364). Has ATP-dependent RNA helicase activity and can unwind double-stranded RNA molecules with a 3' overhang (in vitro) (PubMed:25599396).

Uniprot Accession IDs

• O60306
• A0JP17
• A5YKK3
• Q2YDX9
• Q6IRU8
• Q6PIC8

Gene Name

• AQR

Ensembl ID

• ENST00000156471
• ENSP00000156471
• ENSG00000021776

Symbol

• KIAA0560
• IBP160
• fSAP164

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.88
transcription factor binding site profile	0.82
disease perturbation	0.79
histone modification site profile	0.68
virus perturbation	0.64

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Nuclease / Endoribonuclease / Rna Helicase Aquarius

Protein / Nucleic Acid Binding / Helicase / Rna Helicase / Rna Helicase Aquarius

Protein / Nucleic Acid Binding / Helicase / Dna Helicase / Rna Helicase Aquarius

Protein / Nucleic Acid Binding / Rna Binding Protein / Endoribonuclease / Rna Helicase Aquarius

Protein / Nucleic Acid Binding / Rna Binding Protein / Rna Helicase / Rna Helicase Aquarius

Protein / Nucleic Acid Binding / Dna Binding Protein / Dna Helicase / Rna Helicase Aquarius

Protein / Hydrolase / Rna Helicase Aquarius

DTO Classes

Protein / Enzyme / Helicase / Rna Helicase / Intron-binding Protein Aquarius

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.75   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 77   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.75   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0