You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TRAK2
Trafficking kinesin-binding protein 2

Protein Classes
Protein Summary
Description
May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332624
  • ENSP00000328875
  • ENSG00000115993
  • ENST00000430254
  • ENSP00000409333

Symbol
  • ALS2CR3
  • KIAA0549
  • GRIF1
  • MILT2
  • OIP98
  • CALS-C
  • GRIF-1
  • ALS2CR3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
histone modification site profile
0.81
transcription factor perturbation
0.8
transcription factor binding site profile
0.77
cell line
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.58   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 229   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.58   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 229   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
4
1
1.1
97.2
lymphocyte count
2
2
2
92.9
platelet crit
2
2
2
89.1
keratinocyte carcinoma
1
1
0
1.1
83.8
lymphocyte percentage of leukocytes
2
2
2
83.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
97.2
lymphocyte count
2
92.9
platelet crit
2
89.1
keratinocyte carcinoma
0
1.1
83.8
lymphocyte percentage of leukocytes
2
83.6
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
trafficking kinesin protein 2
VGNC:2893
459876
Mouse
MGI:1918077
70827
Rat
RGD:620915
171086
Dog
trafficking kinesin protein 2
VGNC:47774
488475
Horse
trafficking kinesin protein 2
VGNC:24466
100066224
Species
Name
OMA
EggNOG
Inparanoid
Chimp
trafficking kinesin protein 2
Mouse
Rat
Dog
trafficking kinesin protein 2
Horse
trafficking kinesin protein 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O60296-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (30)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (77)
1 – 10 of 77
TRAK1
Tbio
Novelty:  0.03561577
p_int:  0.999999875
p_ni:  1.25e-7
Score:  0.386
Data Source:  BioPlex,STRINGDB
CARD19
Tbio
Family:  Enzyme
Novelty:  0.18215136
p_int:  0.999998874
p_ni:  4.85e-7
p_wrong:  6.41e-7
Score:  0.183
Data Source:  BioPlex,STRINGDB
KIF5A
Tbio
Novelty:  0.01277095
p_int:  0.999997922
p_ni:  0.000002078
Score:  0.875
Data Source:  BioPlex,STRINGDB
GSK3A
Tclin
Family:  Kinase
Novelty:  0.00925708
p_int:  0.999995924
p_ni:  0.000004045
p_wrong:  3.1e-8
Score:  0.167
Data Source:  BioPlex,STRINGDB
KLC2
Tbio
Novelty:  0.06284367
p_int:  0.999950624
p_ni:  0.000049373
p_wrong:  4e-9
Score:  0.513
Data Source:  BioPlex,STRINGDB
TRIM71
Tbio
Family:  Enzyme
Novelty:  0.01164618
p_int:  0.99985166
p_ni:  0.00014834
Data Source:  BioPlex
GSK3B
Tclin
Family:  Kinase
Novelty:  0.00095115
p_int:  0.999842548
p_ni:  0.000157452
Score:  0.167
Data Source:  BioPlex,STRINGDB
PRKAA1
Tclin
Family:  Kinase
Novelty:  0.01205826
p_int:  0.998716824
p_ni:  0.001283176
Score:  0.611
Data Source:  BioPlex,STRINGDB
ACAD11
Tbio
Family:  Enzyme
Novelty:  0.22908145
p_int:  0.99692113
p_ni:  0.00307887
Data Source:  BioPlex
OGT
Tchem
Family:  Enzyme
Novelty:  0.00290822
p_int:  0.996629581
p_ni:  0.003370419
Score:  0.735
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  25.58

PubMed score by year
PubTator Score  13.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: