You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
LCMT2
tRNA wybutosine-synthesizing protein 4

Protein Summary
Description
Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity). May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues. The protein encoded by this intronless gene belongs to the highly variable methyltransferase superfamily. This gene is the inferred homolog of the Saccharomyces cerevisiae carboxymethyltransferase gene PPM2 that is essential for the synthesis of the hypermodified guanosine Wybutosine (yW). [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305641
  • ENSP00000307214
  • ENSG00000168806

Symbol
  • KIAA0547
  • TYW4
  • PPM2
  • TYW4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
virus perturbation
0.76
histone modification site profile
0.72
pathway
0.62
transcription factor perturbation
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.01   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.01   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (33)
FGL1
Tbio
Novelty:  0.02650803
p_int:  0.999992287
p_ni:  0.000007713
Data Source:  BioPlex
UBAC1
Tbio
Novelty:  0.00122518
p_int:  0.995170292
p_ni:  0.004829704
p_wrong:  3e-9
Score:  0.489
Data Source:  BioPlex,STRINGDB
RNF123
Tbio
Family:  Enzyme
Novelty:  0.01872044
p_int:  0.953224579
p_ni:  0.046775421
Score:  0.529
Data Source:  BioPlex,STRINGDB
IMPDH1
Tclin
Family:  Enzyme
Novelty:  0.00758575
p_int:  0.927879723
p_ni:  0.071446923
p_wrong:  0.000673354
Data Source:  BioPlex
DNAJC7
Tbio
Novelty:  0.02133191
p_int:  0.927575173
p_ni:  0.072424827
Data Source:  BioPlex
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.863768041
p_ni:  0.136231959
Data Source:  BioPlex
TKT
Tchem
Family:  Enzyme
Novelty:  0.00333936
p_int:  0.832653017
p_ni:  0.16659851
p_wrong:  0.000748474
Data Source:  BioPlex
TYW3
Tdark
Novelty:  0.15183348
Score:  0.988
Data Source:  STRINGDB
TRMT12
Tbio
Family:  Enzyme
Novelty:  0.12417204
Score:  0.888
Data Source:  STRINGDB
TRMT5
Tbio
Family:  Enzyme
Novelty:  0.02509765
Score:  0.887
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Synthesis of wybutosine at G37 of tRNA(Phe)
Reactome
tRNA modification in the nucleus and cytosol
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Synthesis of wybutosine at G37 of tRNA(Phe)
tRNA modification in the nucleus and cytosol
tRNA processing
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
1
1
77.4
triglyceride measurement
1
1
1
77.3
eosinophil percentage of leukocytes
1
1
1
67.9
eosinophil count
2
1
2
67.8
hematological measurement
1
1
1
67.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
77.4
triglyceride measurement
1
77.3
eosinophil percentage of leukocytes
1
67.9
eosinophil count
2
67.8
hematological measurement
1
67.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1353659
329504
Rat
RGD:1305829
296098
Dog
leucine carboxyl methyltransferase 2
VGNC:42610
100856672
Cow
leucine carboxyl methyltransferase 2
VGNC:30813
538825
Pig
leucine carboxyl methyltransferase 2
100156590
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
leucine carboxyl methyltransferase 2
Cow
leucine carboxyl methyltransferase 2
Pig
leucine carboxyl methyltransferase 2
Publication Statistics
PubMed Score 23.01
PubMed score by year
PubTator Score 5.30
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title