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Tbio
SIPA1L3
Signal-induced proliferation-associated 1-like protein 3

Protein Summary
Description
Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). This gene belongs to the signal induced proliferation associated 1 family of genes, which encode GTPase-activating proteins specific for the GTP-binding protein Rap1. Rap1 has been implicated in regulation of cell adhesion, cell polarity, and organization of the cytoskeleton. Like other members of the family, the protein encoded by this gene contains RapGAP and PDZ domains. In addition, this protein contains a C-terminal leucine zipper domain. This gene is proposed to function in epithelial cell morphogenesis and establishment or maintenance of polarity. Consistently, expression of the protein in cell culture showed localization to cell-cell borders in apical regions, and downregulation of the gene in 3D Caco2 cell culture resulted in abnormal cell polarity and morphogenesis. Allelic variants of this gene have been associated with congenital cataracts ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222345
  • ENSP00000222345
  • ENSG00000105738

Symbol
  • KIAA0545
  • SPAL3
  • SPAL3
  • SPAR3
  • CTRCT45
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.83
interacting protein
0.78
histone modification site profile
0.76
disease perturbation
0.68
cell type or tissue
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.73   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 60   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.73   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 60   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
3
0
1.1
92.5
glomerular filtration rate
3
4
3
5.5
90.9
platelet count
2
2
2
85.2
mathematical ability
2
2
2
63
serum gamma-glutamyl transferase measurement
1
1
1
59
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
92.5
glomerular filtration rate
3
5.5
90.9
platelet count
2
85.2
mathematical ability
2
63
serum gamma-glutamyl transferase measurement
1
59
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
signal induced proliferation associated 1 like 3
VGNC:10265
468861
Macaque
signal induced proliferation associated 1 like 3
714601
Mouse
MGI:1921456
74206
Dog
signal induced proliferation associated 1 like 3
VGNC:46182
612583
Cow
signal induced proliferation associated 1 like 3
VGNC:53042
513625
Species
Name
OMA
EggNOG
Inparanoid
Chimp
signal induced proliferation associated 1 like 3
Macaque
signal induced proliferation associated 1 like 3
Mouse
Dog
signal induced proliferation associated 1 like 3
Cow
signal induced proliferation associated 1 like 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O60292-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (12)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (37)
1 – 10 of 37
SIPA1
Tbio
Novelty:  0.03916566
p_int:  0.999999953
p_ni:  4.6e-8
p_wrong:  1e-9
Data Source:  BioPlex
SPIN2A
Tdark
Novelty:  0.12795054
p_int:  0.999987809
p_ni:  0.000003553
p_wrong:  0.000008637
Data Source:  BioPlex
SIPA1L1
Tdark
Novelty:  0.13134052
p_int:  0.999976829
p_ni:  0.000023171
Data Source:  BioPlex
LZTS2
Tbio
Novelty:  0.09515452
p_int:  0.999063743
p_ni:  0.000003572
p_wrong:  0.000932685
Score:  0.384
Data Source:  BioPlex,STRINGDB
SIPA1L2
Tbio
Novelty:  0.2002618
p_int:  0.999046062
p_ni:  0.000953934
p_wrong:  5e-9
Data Source:  BioPlex
GOLM1
Tbio
Novelty:  0.00752112
p_int:  0.997106567
p_ni:  0.002893433
Data Source:  BioPlex
WDR83
Tbio
Novelty:  0.11602568
p_int:  0.988911952
p_ni:  0.010543692
p_wrong:  0.000544356
Score:  0.181
Data Source:  BioPlex,STRINGDB
YWHAG
Tchem
Novelty:  0.00845572
p_int:  0.950088354
p_ni:  0.049911646
Data Source:  BioPlex
YWHAE
Tbio
Novelty:  0.00431876
p_int:  0.948234781
p_ni:  0.051765219
Data Source:  BioPlex
YWHAQ
Tchem
Novelty:  0.00234496
p_int:  0.946775709
p_ni:  0.053224291
Score:  0.231
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  8.73

PubMed score by year
PubTator Score  2.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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