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Tchem
NUAK1
NUAK family SNF1-like kinase 1

Protein Summary
Description
Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate to transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppre ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261402
  • ENSP00000261402
  • ENSG00000074590

Symbol
  • ARK5
  • KIAA0537
  • OMPHK1
  • ARK5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
virus perturbation
0.88
PubMedID
0.87
transcription factor perturbation
0.84
gene perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.98   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 293   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.98   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 293   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 12
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (6)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
Regulation of TP53 Activity
Reactome
Regulation of TP53 Activity through Phosphorylation
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Regulation of TP53 Activity
Regulation of TP53 Activity through Phosphorylation
Gene Ontology Terms (18)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (32)
1 – 10 of 32
BTRC
Tbio
Novelty: 0.00393331
p_int: 0.99848465
p_ni: 0.00151535
Score: 0.592
Data Source: BioPlex,STRINGDB
FBXW11
Tbio
Novelty: 0.14703388
p_int: 0.972651055
p_ni: 0.027348944
Score: 0.705
Data Source: BioPlex,STRINGDB
STK11
Tchem
Family: Kinase
Novelty: 0.00094968
Score: 0.946
Data Source: Reactome,STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00002203
Score: 0.943
Data Source: Reactome,STRINGDB
ATM
Tchem
Family: Kinase
Novelty: 0.00023967
Score: 0.856
Data Source: STRINGDB
PPP1R12A
Tbio
Family: Enzyme
Novelty: 0.00135446
Score: 0.784
Data Source: STRINGDB
USP9X
Tbio
Family: Enzyme
Novelty: 0.00164293
Score: 0.74
Data Source: STRINGDB
CASP6
Tchem
Family: Enzyme
Novelty: 0.00311641
Score: 0.727
Data Source: STRINGDB
AASS
Tbio
Family: Enzyme
Novelty: 0.04078858
Score: 0.665
Data Source: STRINGDB
CDKN1A
Tbio
Family: Enzyme
Novelty: 0.00038005
Score: 0.64
Data Source: STRINGDB
Publication Statistics
PubMed Score  51.98

PubMed score by year
PubTator Score  31.88

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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