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Tbio
KIF5C
Kinesin heavy chain isoform 5C

Protein Summary
Description
Involved in synaptic transmission (PubMed:24812067). Mediates dendritic trafficking of mRNAs (By similarity). Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). The protein encoded by this gene is a kinesin heavy chain subunit involved in the transport of cargo within the central nervous system. The encoded protein, which acts as a tetramer by associating with another heavy chain and two light chains, interacts with protein kinase CK2. Mutations in this gene have been associated with complex cortical dysplasia with other brain malformations-2. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Jul 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000435030
  • ENSP00000393379
  • ENSG00000168280

Symbol
  • KIAA0531
  • NKHC2
  • KINN
  • NKHC
  • NKHC2
  • CDCBM2
  • NKHC-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
gene perturbation
0.94
disease perturbation
0.79
microRNA
0.75
small molecule perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.91   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.91   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (137)
1 – 10 of 137
KLC1
Tbio
Novelty:  0.00653484
p_int:  0.999996424
p_ni:  0.000003576
Score:  0.971
Data Source:  BioPlex,STRINGDB
SYNE4
Tbio
Novelty:  0.0739848
p_int:  0.999976112
p_ni:  0.000023888
Score:  0.219
Data Source:  BioPlex,STRINGDB
MYCL
Tbio
Family:  TF
Novelty:  0.0034508
p_int:  0.999860384
p_ni:  0.000139616
Score:  0.177
Data Source:  BioPlex,STRINGDB
TRIP6
Tbio
Novelty:  0.02183202
p_int:  0.999217258
p_ni:  0.000782742
Score:  0.241
Data Source:  BioPlex,STRINGDB
COG6
Tbio
Novelty:  0.02874093
p_int:  0.997085852
p_ni:  0.002914148
Score:  0.224
Data Source:  BioPlex,STRINGDB
TRAK2
Tbio
Novelty:  0.04192075
p_int:  0.9918332
p_ni:  0.0081668
Score:  0.856
Data Source:  BioPlex,STRINGDB
BRK1
Tbio
Novelty:  0.02289534
p_int:  0.986285868
p_ni:  0.013714132
Data Source:  BioPlex
EXOC1
Tbio
Novelty:  0.01073858
p_int:  0.937785636
p_ni:  0.062214364
Data Source:  BioPlex
NUP62
Tbio
Novelty:  0.01432724
p_int:  0.936695071
p_ni:  0.063304929
Data Source:  BioPlex
AZIN1
Tbio
Family:  Enzyme
Novelty:  0.03017595
p_int:  0.812226671
p_ni:  0.187773329
Score:  0.719
Data Source:  BioPlex,STRINGDB
Pathways (16)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Golgi-to-ER retrograde transport
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
COPI-dependent Golgi-to-ER retrograde traffic
Factors involved in megakaryocyte development and platelet production
Golgi-to-ER retrograde transport
Hemostasis
Gene Ontology Terms (22)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical surface area measurement
1
1
0
1.9
39.6
1
1
0
1.1
5.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical surface area measurement
0
1.9
39.6
0
1.1
5.3
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 5C
VGNC:1983
470557
Mouse
MGI:1098269
16574
Dog
kinesin family member 5C
VGNC:42409
476144
Horse
kinesin family member 5C
VGNC:19423
100056413
Cow
kinesin family member 5C
VGNC:30607
538771
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 5C
Mouse
Dog
kinesin family member 5C
Horse
kinesin family member 5C
Cow
kinesin family member 5C
Publication Statistics
PubMed Score 40.91
PubMed score by year
PubTator Score 20.95
PubTator score by year