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Tbio
ZNF292
Zinc finger protein 292

Protein Summary
Description
May be involved in transcriptional regulation. This gene encodes a growth hormone-dependent, zinc finger transcription factor that functions as a tumor suppressor. Naturally occurring mutations in this gene are associated with gastric cancer, colorectal cancer, and chronic lymphocytic leukemia. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369577
  • ENSP00000358590
  • ENSG00000188994

Symbol
  • KIAA0530
  • ZN-16
  • Zn-15
  • ZFP292
  • Nbla00365
  • bA393I2.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
disease perturbation
0.9
transcription factor
0.71
transcription factor binding site profile
0.71
virus perturbation
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.04   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 47   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.04   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 47   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
82.2
myeloid white cell count
1
1
1
73.5
neutrophil percentage of leukocytes
2
2
2
61.9
lymphocyte percentage of leukocytes
2
2
2
56.3
eosinophil percentage of leukocytes
1
1
1
46.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
82.2
myeloid white cell count
1
73.5
neutrophil percentage of leukocytes
2
61.9
lymphocyte percentage of leukocytes
2
56.3
eosinophil percentage of leukocytes
1
46.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 292
VGNC:7945
462870
Macaque
zinc finger protein 292
700157
Mouse
MGI:1353423
30046
Rat
RGD:61931
50552
Dog
zinc finger protein 292
VGNC:48691
481908
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 292
Macaque
zinc finger protein 292
Mouse
Rat
Dog
zinc finger protein 292
Protein Structure (1 Structure, 8 AlphaFold Models)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (5)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (35)
1 – 10 of 35
GJB7
Tbio
Novelty: 0.12555147
Score: 0.727
Data Source: STRINGDB
ORC3
Tbio
Novelty: 0.03409802
Score: 0.722
Data Source: STRINGDB
RARS2
Tbio
Family: Enzyme
Novelty: 0.01185296
Score: 0.706
Data Source: STRINGDB
AKIRIN2
Tbio
Novelty: 0.04603317
Score: 0.699
Data Source: STRINGDB
GABRR1
Tchem
Family: IC
Novelty: 0.01601481
Score: 0.684
Data Source: STRINGDB
RNGTT
Tbio
Novelty: 0.01433659
Score: 0.678
Data Source: STRINGDB
MOB3B
Tbio
Family: Enzyme
Novelty: 0.16818316
Score: 0.668
Data Source: STRINGDB
AKIRIN1
Tbio
Novelty: 0.16318877
Score: 0.64
Data Source: STRINGDB
SYNCRIP
Tbio
Novelty: 0.01479381
Score: 0.636
Data Source: STRINGDB
FAM189A2
Tdark
Novelty: 0.41335428
Score: 0.578
Data Source: STRINGDB
Publication Statistics
PubMed Score  19.04

PubMed score by year
PubTator Score  6.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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