Tbio SPAG9 C-Jun-amino-terminal kinase-interacting protein 4

Protein Summary

Description

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Isoform 5 may play a role in spermatozoa-egg-interaction. This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• O60271
• A6H8U5
• A8MSX0
• B4DHH2
• O60905
• Q3KQU8
• Q3MKM7
• Q86WC7
• Q86WC8
• Q8IZX7
• Q96II0
• Q9H811
• JIP-4

Gene Name

• SPAG9

Ensembl ID

• ENST00000262013
• ENSP00000262013
• ENSG00000008294
• ENST00000357122
• ENSP00000349636
• ENST00000505279
• ENSP00000426900
• ENST00000510283
• ENSP00000423165

Symbol

• HSS
• KIAA0516
• MAPK8IP4
• SYD1
• JLP
• CT89
• HLC4
• HLC6
• JIP4
• PHET
• PIG6
• HLC-6
• JIP-4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.97
virus perturbation	0.94
transcription factor perturbation	0.91
hub protein	0.9
biological process	0.87

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Kinase Modulator / C-jun-amino-terminal Kinase-interacting Protein 4

DTO Classes

Protein / Enzyme Modulator / Kinase Modulator / C-jun-amino-terminal Kinase-interacting Protein 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.37   (req: < 5)

Gene RIFs: 44   (req: <= 3)

Antibodies: 195   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.37   (req: >= 5)

Gene RIFs: 44   (req: > 3)

Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0