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Tbio
SMARCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

Protein Classes
Protein Summary
Description
Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. Essential component of the NoRC (nucleolar r ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000283131
  • ENSP00000283131
  • ENSG00000153147

Symbol
  • SNF2H
  • WCRF135
  • ISWI
  • SNF2H
  • hISWI
  • hSNF2H
  • WCRF135
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
protein domain
1
protein complex
0.99
molecular function
0.98
virus perturbation
0.98


Related Tools
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 194.56   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 354   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 194.56   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 354   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
461517
Macaque
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
700614
Mouse
MGI:1935129
93762
Rat
RGD:1308832
307766
Dog
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
VGNC:46531
475451
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
Macaque
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
Mouse
Rat
Dog
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O60264-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (15)
B-WICH complex positively regulates rRNA expression (R-HSA-5250924)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
B-WICH complex positively regulates rRNA expression
Reactome
Cell Cycle
Reactome
Chromosome Maintenance
Reactome
DNA Double Strand Break Response
Reactome
DNA Double-Strand Break Repair
Name
Explore in Pharos
Explore in Source
B-WICH complex positively regulates rRNA expression
Cell Cycle
Chromosome Maintenance
DNA Double Strand Break Response
DNA Double-Strand Break Repair
Gene Ontology Terms (24)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (336)
1 – 10 of 336
RBBP7
Tbio
Novelty: 0.01795364
p_int: 0.999903976
p_ni: 0.000096024
Score: 0.977
Data Source: BioPlex,STRINGDB
POLE3
Tbio
Family: Enzyme
Novelty: 0.09657513
p_int: 0.992389097
p_ni: 0.007610903
Score: 0.935
Data Source: BioPlex,STRINGDB
DAXX
Tbio
Novelty: 0.00348585
p_int: 0.899020398
p_ni: 0.1009796
p_wrong: 2e-9
Score: 0.591
Data Source: BioPlex,STRINGDB
RPL30
Tbio
Novelty: 0.0134194
p_int: 0.756896949
p_ni: 0.243103051
Score: 0.202
Data Source: BioPlex,STRINGDB
BAZ1B
Tbio
Family: Epigenetic
Novelty: 0.02374034
Score: 0.999
Data Source: Reactome,STRINGDB
BAZ1A
Tbio
Family: Epigenetic
Novelty: 0.01833837
Score: 0.998
Data Source: STRINGDB
BPTF
Tchem
Family: Epigenetic
Novelty: 0.00826037
Score: 0.997
Data Source: STRINGDB
CHRAC1
Tbio
Novelty: 0.17492099
Score: 0.997
Data Source: STRINGDB
HDAC2
Tclin
Family: Epigenetic
Novelty: 0.0011024
Score: 0.995
Data Source: STRINGDB
HDAC1
Tclin
Family: Epigenetic
Novelty: 0.00065244
Score: 0.995
Data Source: STRINGDB
Publication Statistics
PubMed Score  194.56

PubMed score by year
PubTator Score  70.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer