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Tbio
GNG7
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7

Protein Summary
Description
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382159
  • ENSP00000371594
  • ENSG00000176533

Symbol
  • GNGT7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.91
transcription factor
0.69
biological process
0.64
virus perturbation
0.64
tissue sample
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.52   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.52   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (924)
GNAI3
Tbio
Novelty:  0.03484857
p_int:  0.998606187
p_ni:  0.000821092
p_wrong:  0.000572721
Score:  0.982
Data Source:  BioPlex,STRINGDB
GNAI2
Tchem
Novelty:  0.03014729
p_int:  0.994880434
p_ni:  0.005119432
p_wrong:  1.34e-7
Score:  0.973
Data Source:  BioPlex,STRINGDB
SLC25A41
Tdark
Family:  Transporter
Novelty:  1.04918395
p_int:  0.993229321
p_ni:  0.004805023
p_wrong:  0.001965657
Data Source:  BioPlex
GNAI1
Tbio
Novelty:  0.0488971
p_int:  0.952904384
p_ni:  0.004433813
p_wrong:  0.042661803
Score:  0.983
Data Source:  BioPlex,STRINGDB
GNA13
Tbio
Novelty:  0.04149138
p_int:  0.79605937
p_ni:  0.155345709
p_wrong:  0.048594921
Score:  0.949
Data Source:  BioPlex,STRINGDB
CITED1
Tbio
Novelty:  0.01956689
p_int:  0.789747288
p_ni:  0.193019287
p_wrong:  0.017233425
Data Source:  BioPlex
NUFIP1
Tbio
Novelty:  0.11726869
p_int:  0.765132713
p_ni:  0.041512569
p_wrong:  0.193354718
Data Source:  BioPlex
GNB4
Tbio
Novelty:  0.08250797
Score:  0.999
Data Source:  STRINGDB
GNB2
Tbio
Novelty:  0.08682553
Score:  0.999
Data Source:  STRINGDB
GNB3
Tbio
Novelty:  0.0037117
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets (26)
Explore Nearest Tclin Targets
1 – 5 of 16
F2R
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
CHRM1
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
CHRM2
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
CNR1
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  1
GABBR1
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
Pathways (112)
ADP signalling through P2Y purinoceptor 1 (R-HSA-418592)

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Items per page:
1 – 5 of 59
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ADP signalling through P2Y purinoceptor 1
Reactome
ADP signalling through P2Y purinoceptor 12
Reactome
Activation of G protein gated Potassium channels
Reactome
Activation of GABAB receptors
Reactome
Activation of kainate receptors upon glutamate binding
Name
Explore in Pharos
Explore in Source
ADP signalling through P2Y purinoceptor 1
ADP signalling through P2Y purinoceptor 12
Activation of G protein gated Potassium channels
Activation of GABAB receptors
Activation of kainate receptors upon glutamate binding
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
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Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
3
6
94.6
testosterone measurement
3
3
3
90.1
heel bone mineral density
2
1
2
80.3
C-reactive protein measurement
2
1
2
46.5
low density lipoprotein cholesterol measurement
1
1
1
36.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
94.6
testosterone measurement
3
90.1
heel bone mineral density
2
80.3
C-reactive protein measurement
2
46.5
low density lipoprotein cholesterol measurement
1
36.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:95787
14708
Rat
RGD:61860
58979
Dog
G protein subunit gamma 7
VGNC:41322
612139
Horse
G protein subunit gamma 7
VGNC:18435
100059736
Cow
G protein subunit gamma 7
VGNC:29468
618399
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
G protein subunit gamma 7
Horse
G protein subunit gamma 7
Cow
G protein subunit gamma 7
Publication Statistics
PubMed Score 22.52
PubMed score by year
PubTator Score 3.55
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title