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Tbio
PRKN
E3 ubiquitin-protein ligase parkin

Protein Summary
Description
Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPT5, TOMM20, USP30, ZNF746 and AIMP2 (PubMed:10973942, PubMed:10888878, PubMed:11431533, PubMed:12150907, PubMed:12628165, PubMed:16135753, PubMed:21376232, PubMed:23754282, PubMed:23620051, PubMed:24660806, PubMed:24751536). Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context (PubMed:19229105, PubMed:20889974, PubMed:25621951). Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation (PubMed:17846173, PubMe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338468
  • ENSP00000343589
  • ENSG00000185345
  • ENST00000366894
  • ENSP00000355860
  • ENST00000366896
  • ENSP00000355862
  • ENST00000366897
  • ENSP00000355863
  • ENST00000366898
  • ENSP00000355865
  • ENST00000479615
  • ENSP00000434414

Symbol
  • PARK2
  • PDJ
  • AR-JP
  • LPRS2
  • PARK2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1356.26   (req: < 5)
Gene RIFs: 545   (req: <= 3)
Antibodies: 717   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1356.26   (req: >= 5)
Gene RIFs: 545   (req: > 3)
Antibodies: 717   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 127
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
9
1
15
95
self reported educational attainment
1
1
1
77.2
age at onset
1
1
0
4.1
73.2
1
1
0
4.1
73.2
mathematical ability
1
1
1
66.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
15
95
self reported educational attainment
1
77.2
age at onset
0
4.1
73.2
0
4.1
73.2
mathematical ability
1
66.7
Protein Data Bank (13)
1 – 5 of 13
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (10)
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Ubiquitin mediated proteolysis
KEGG
Protein processing in endoplasmic reticulum
KEGG
Mitophagy - animal
KEGG
Parkinson disease
Name
Explore in Pharos
Explore in Source
Ubiquitin mediated proteolysis
Protein processing in endoplasmic reticulum
Mitophagy - animal
Parkinson disease
Gene Ontology Terms (141)
Items per page:
10
1 – 10 of 26
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Protein-Protein Interactions (493)
1 – 10 of 493
TNFRSF17
Tbio
Novelty: 0.00222663
p_int: 0.999721603
p_ni: 0.000277752
p_wrong: 6.45e-7
Score: 0.232
Data Source: BioPlex,STRINGDB
PCYT2
Tbio
Family: Enzyme
Novelty: 0.03267621
p_int: 0.997945413
p_ni: 0.002054587
Score: 0.455
Data Source: BioPlex,STRINGDB
BBOX1
Tchem
Family: Enzyme
Novelty: 0.00255489
p_int: 0.988534574
p_ni: 0.011465426
Score: 0.243
Data Source: BioPlex,STRINGDB
VCP
Tchem
Family: Enzyme
Novelty: 0.00103317
p_int: 0.976711077
p_ni: 0.023288923
Score: 0.624
Data Source: BioPlex,STRINGDB
PASK
Tbio
Family: Kinase
Novelty: 0.14004084
p_int: 0.958068458
p_ni: 0.041931542
Score: 0.42
Data Source: BioPlex,STRINGDB
PINK1
Tbio
Family: Kinase
Novelty: 0.00100973
Score: 0.999
Data Source: Reactome,STRINGDB
UBC
Tbio
Novelty: 0.00204643
Score: 0.993
Data Source: STRINGDB
SNCA
Tchem
Novelty: 0.00012042
Score: 0.992
Data Source: STRINGDB
UBB
Tbio
Novelty: 0.00661254
Score: 0.992
Data Source: STRINGDB
MFN1
Tbio
Novelty: 0.00372574
Score: 0.99
Data Source: STRINGDB
Publication Statistics
PubMed Score  1356.26

PubMed score by year
PubTator Score  379.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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