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Tbio
PRKN
E3 ubiquitin-protein ligase parkin

Protein Summary
Description
Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPT5, TOMM20, USP30, ZNF746 and AIMP2 (PubMed:10973942, PubMed:10888878, PubMed:11431533, PubMed:12150907, PubMed:12628165, PubMed:16135753, PubMed:21376232, PubMed:23754282, PubMed:23620051, PubMed:24660806, PubMed:24751536). Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context (PubMed:19229105, PubMed:20889974, PubMed:25621951). Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation (PubMed:17846173, PubMe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338468
  • ENSP00000343589
  • ENSG00000185345
  • ENST00000366894
  • ENSP00000355860
  • ENST00000366896
  • ENSP00000355862
  • ENST00000366897
  • ENSP00000355863
  • ENST00000366898
  • ENSP00000355865
  • ENST00000479615
  • ENSP00000434414

Symbol
  • PARK2
  • PDJ
  • AR-JP
  • LPRS2
  • PARK2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1356.26   (req: < 5)
Gene RIFs: 545   (req: <= 3)
Antibodies: 717   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1356.26   (req: >= 5)
Gene RIFs: 545   (req: > 3)
Antibodies: 717   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 127
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
9
1
15
95
self reported educational attainment
1
1
1
77.2
age at onset
1
1
0
4.1
73.2
1
1
0
4.1
73.2
mathematical ability
1
1
1
66.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
15
95
self reported educational attainment
1
77.2
age at onset
0
4.1
73.2
0
4.1
73.2
mathematical ability
1
66.7
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
parkin RBR E3 ubiquitin protein ligase
VGNC:13029
741350
Macaque
parkin RBR E3 ubiquitin protein ligase
710899
Mouse
MGI:1355296
50873
Horse
parkin RBR E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:8607]
Cow
parkin RBR E3 ubiquitin protein ligase
VGNC:33342
530858
Species
Name
OMA
EggNOG
Inparanoid
Chimp
parkin RBR E3 ubiquitin protein ligase
Macaque
parkin RBR E3 ubiquitin protein ligase
Mouse
Horse
parkin RBR E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:8607]
Cow
parkin RBR E3 ubiquitin protein ligase
Protein Structure (13 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O60260-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 13
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Ubiquitin mediated proteolysis
KEGG
Protein processing in endoplasmic reticulum
KEGG
Mitophagy - animal
KEGG
Parkinson disease
Name
Explore in Pharos
Explore in Source
Ubiquitin mediated proteolysis
Protein processing in endoplasmic reticulum
Mitophagy - animal
Parkinson disease
Gene Ontology Terms (141)
Items per page:
10
1 – 10 of 26
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Protein-Protein Interactions (493)
1 – 10 of 493
TNFRSF17
Tbio
Novelty: 0.00222663
p_int: 0.999721603
p_ni: 0.000277752
p_wrong: 6.45e-7
Score: 0.232
Data Source: BioPlex,STRINGDB
PCYT2
Tbio
Family: Enzyme
Novelty: 0.03267621
p_int: 0.997945413
p_ni: 0.002054587
Score: 0.455
Data Source: BioPlex,STRINGDB
BBOX1
Tchem
Family: Enzyme
Novelty: 0.00255489
p_int: 0.988534574
p_ni: 0.011465426
Score: 0.243
Data Source: BioPlex,STRINGDB
VCP
Tchem
Family: Enzyme
Novelty: 0.00103317
p_int: 0.976711077
p_ni: 0.023288923
Score: 0.624
Data Source: BioPlex,STRINGDB
PASK
Tbio
Family: Kinase
Novelty: 0.14004084
p_int: 0.958068458
p_ni: 0.041931542
Score: 0.42
Data Source: BioPlex,STRINGDB
PINK1
Tbio
Family: Kinase
Novelty: 0.00100973
Score: 0.999
Data Source: Reactome,STRINGDB
UBC
Tbio
Novelty: 0.00204643
Score: 0.993
Data Source: STRINGDB
SNCA
Tchem
Novelty: 0.00012042
Score: 0.992
Data Source: STRINGDB
UBB
Tbio
Novelty: 0.00661254
Score: 0.992
Data Source: STRINGDB
MFN1
Tbio
Novelty: 0.00372574
Score: 0.99
Data Source: STRINGDB
Publication Statistics
PubMed Score  1356.26

PubMed score by year
PubTator Score  379.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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