Tchem KLK8 Kallikrein-8

Protein Summary

Description

Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in tandem in a gene cluster on chromosome 19. The encoded protein may be involved in proteolytic cascade in the skin and may serve as a biomarker for ovarian cancer. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• O60259
• Q5V9X1
• Q5V9X2
• Q8IW69
• Q9HCB3
• Q9NR68
• Q9NR69
• Q9UIL9
• Q9UQ47
• hK8

Gene Name

• KLK8

Ensembl ID

• ENST00000320838
• ENSP00000325072
• ENSG00000129455
• ENST00000347619
• ENSP00000341555
• ENST00000391806
• ENSP00000375682
• ENST00000593490
• ENSP00000469278
• ENST00000600767
• ENSP00000472016

Symbol

• NRPN
• PRSS19
• TADG14
• NP
• HNP
• NRPN
• PRSS19
• TADG14

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.74
cell type or tissue	0.71
biological process	0.63
protein domain	0.58
chemical	0.53

Protein Classes

PANTHER Classes

Protein / ... / Serine Protease / Kallikrein-8

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Kallikrein-8

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.26   (req: < 5)

Gene RIFs: 28   (req: <= 3)

Antibodies: 1037   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.26   (req: >= 5)

Gene RIFs: 28   (req: > 3)

Antibodies: 1037   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 15

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0