You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PCDH7
Protocadherin-7

Protein Summary
Description
This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes a protein with an extracellular domain containing 7 cadherin repeats. The gene product is an integral membrane protein that is thought to function in cell-cell recognition and adhesion. Alternative splicing yields isoforms with unique cytoplasmic tails. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361762
  • ENSP00000355243
  • ENSG00000169851
  • ENST00000543491
  • ENSP00000441802

Symbol
  • BHPCDH
  • BHPCDH
  • BH-Pcdh
  • PPP1R120
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
PubMedID
0.9
microRNA
0.8
protein domain
0.73
disease
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.91   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 298   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.91   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 298   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
2
5
5
83.1
smoking status measurement
2
1
2
69.5
risky sexual behaviour measurement
1
2
2
65.7
comparative body size at age 10, self-reported
1
1
1
65.6
smoking initiation
1
1
1
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
5
83.1
smoking status measurement
2
69.5
risky sexual behaviour measurement
2
65.7
comparative body size at age 10, self-reported
1
65.6
smoking initiation
1
54.4
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protocadherin 7
VGNC:660
461157
Macaque
protocadherin 7
696011
Mouse
MGI:1860487
54216
Rat
RGD:1303209
360942
Dog
protocadherin 7
VGNC:53195
488843
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protocadherin 7
Macaque
protocadherin 7
Mouse
Rat
Dog
protocadherin 7
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O60245-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Name
Explore in Pharos
Explore in Source
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (47)
1 – 10 of 47
XAGE1A
Tbio
Novelty:  0.04421526
p_int:  0.99973101
p_ni:  0.00026899
Data Source:  BioPlex
PCDHGB1
Tdark
Novelty:  0.60440805
p_int:  0.998996752
p_ni:  0.001003248
Score:  0.177
Data Source:  BioPlex,STRINGDB
C2orf48
Tdark
Novelty:  1
p_int:  0.998324915
p_ni:  0.001675085
Score:  0.638
Data Source:  BioPlex,STRINGDB
FLRT1
Tdark
Novelty:  0.23047852
p_int:  0.991796407
p_ni:  0.008203593
Data Source:  BioPlex
UCN3
Tbio
Novelty:  0.00996251
p_int:  0.989039028
p_ni:  0.010960972
Data Source:  BioPlex
LAG3
Tbio
Novelty:  0.00187736
p_int:  0.986697726
p_ni:  0.013302274
Data Source:  BioPlex
TMEM30B
Tbio
Novelty:  0.26735006
p_int:  0.985676218
p_ni:  0.014323782
Data Source:  BioPlex
NXPH2
Tdark
Novelty:  0.65790631
p_int:  0.978281926
p_ni:  0.021718074
Score:  0.333
Data Source:  BioPlex,STRINGDB
FCGR1A
Tclin
Novelty:  0.00073204
p_int:  0.96363898
p_ni:  0.03636102
Score:  0.795
Data Source:  BioPlex,STRINGDB
PCDH20
Tbio
Novelty:  0.07862843
p_int:  0.959677876
p_ni:  0.040322124
Score:  0.713
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  35.91

PubMed score by year
PubTator Score  12.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: