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Tbio
MED14
Mediator of RNA polymerase II transcription subunit 14

Protein Summary
Description
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit comp ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324817
  • ENSP00000323720
  • ENSG00000180182

Symbol
  • ARC150
  • CRSP2
  • CXorf4
  • DRIP150
  • EXLM1
  • RGR1
  • TRAP170
  • CSRP
  • RGR1
  • CRSP2
  • EXLM1
  • CXorf4
  • CRSP150
  • DRIP150
  • TRAP170
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.98
virus perturbation
0.94
interacting protein
0.91
kinase perturbation
0.84
disease perturbation
0.83


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.56   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.56   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mediator complex subunit 14
VGNC:2699
465578
Macaque
mediator complex subunit 14
699395
Mouse
MGI:1349442
26896
Rat
RGD:1560170
317343
Dog
mediator complex subunit 14
VGNC:43124
480884
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mediator complex subunit 14
Macaque
mediator complex subunit 14
Mouse
Rat
Dog
mediator complex subunit 14
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O60244-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Developmental Biology
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism
Metabolism of lipids
Gene Ontology Terms (17)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (159)
1 – 10 of 159
MED21
Tbio
Family:  Enzyme
Novelty:  0.06996616
p_int:  0.999999907
p_ni:  9.3e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
MED19
Tbio
Family:  Enzyme
Novelty:  0.03926689
p_int:  0.999999827
p_ni:  1.73e-7
Score:  0.997
Data Source:  BioPlex,STRINGDB
MED17
Tbio
Family:  Enzyme
Novelty:  0.02984503
p_int:  0.999999566
p_ni:  4.34e-7
Score:  0.998
Data Source:  BioPlex,STRINGDB
MED18
Tbio
Family:  Enzyme
Novelty:  0.04066825
p_int:  0.99999951
p_ni:  4.9e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
MED1
Tbio
Family:  Enzyme
Novelty:  0.00852082
p_int:  0.999999488
p_ni:  5.12e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
MED20
Tbio
Family:  Enzyme
Novelty:  0.02039559
p_int:  0.999998835
p_ni:  0.000001165
Score:  0.996
Data Source:  BioPlex,STRINGDB
MED10
Tdark
Family:  Enzyme
Novelty:  0.02988632
p_int:  0.999998697
p_ni:  0.000001303
Score:  0.999
Data Source:  BioPlex,STRINGDB
MED28
Tbio
Family:  Enzyme
Novelty:  0.00362108
p_int:  0.999998696
p_ni:  0.000001304
Score:  0.999
Data Source:  BioPlex,STRINGDB
MED4
Tbio
Family:  Enzyme
Novelty:  0.01200585
p_int:  0.999998532
p_ni:  0.000001468
Score:  0.996
Data Source:  BioPlex,STRINGDB
CCNC
Tbio
Novelty:  0.00585842
p_int:  0.999997074
p_ni:  0.000002926
Score:  0.996
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  62.56

PubMed score by year
PubTator Score  17.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer