Tbio MED14 Mediator of RNA polymerase II transcription subunit 14

Protein Summary

Description

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O60244
• Q4KMR7
• Q9UNB3

Gene Name

• MED14

Ensembl ID

• ENST00000324817
• ENSP00000323720
• ENSG00000180182

Symbol

• ARC150
• CRSP2
• CXorf4
• DRIP150
• EXLM1
• RGR1
• TRAP170
• CSRP
• RGR1
• CRSP2
• EXLM1
• CXorf4
• CRSP150
• DRIP150
• TRAP170

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.98
virus perturbation	0.94
interacting protein	0.91
kinase perturbation	0.84
disease perturbation	0.83

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Mediator Of Rna Polymerase Ii Transcription Subunit 14

Protein / Receptor / Mediator Of Rna Polymerase Ii Transcription Subunit 14

DTO Classes

Protein / Transcription Factor / Transcription Cofactor / Mediator Of Rna Polymerase Ii Transcription Subunit 14

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.31   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 147   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.31   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0