Tbio HS6ST1 Heparan-sulfate 6-O-sulfotransferase 1

Protein Summary

Description

6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Critical for normal neuronal development where it may play a role in neuron branching. May also play a role in limb development. May prefer iduronic acid. The protein encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biological activities. This enzyme is a type II integral membrane protein and is responsible for 6-O-sulfation of heparan sulfate. This enzyme does not share significant sequence similarity with other known sulfotransferases. A pseudogene located on chromosome 1 has been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O60243
• B4DEP2
• B4DJ29
• Q53SL2
• Q9BVI1
• HS6ST-1

Gene Name

• HS6ST1

Ensembl ID

• ENST00000259241
• ENSP00000259241
• ENSG00000136720

Symbol

• HS6ST
• HH15
• HS6ST

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.9
transcription factor binding site profile	0.76
PubMedID	0.71
tissue sample	0.69
transcription factor perturbation	0.61

Protein Classes

PANTHER Classes

Protein / Transferase / Heparan-sulfate 6-o-sulfotransferase 1

DTO Classes

Protein / Enzyme / Transferase / Heparan-sulfate 6-o-sulfotransferase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.96   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 102   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.96   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0