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Tbio
ADGRB3
Adhesion G protein-coupled receptor B3

Protein Summary
Description
Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity (By similarity). Promotes myoblast fusion through ELMO/DOCK1 (PubMed:24567399). This p53-target gene encodes a brain-specific angiogenesis inhibitor, a seven-span transmembrane protein, and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities, and may also play a role in angiogenesis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370598
  • ENSP00000359630
  • ENSG00000135298
  • ENST00000546190
  • ENSP00000441821

Symbol
  • BAI3
  • KIAA0550
  • BAI3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
trait
0.99
gene perturbation
0.78
virus perturbation
0.76
transcription factor
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.42   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 196   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.42   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 196   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (17)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (27)
1 – 10 of 27
ELMO1
Tbio
Novelty: 0.01956016
Score: 0.789
Data Source: STRINGDB
C1QL1
Tdark
Novelty: 0.19017433
Score: 0.782
Data Source: STRINGDB
FBXO16
Tdark
Novelty: 0.68965517
Score: 0.658
Data Source: STRINGDB
SH3GL2
Tbio
Novelty: 0.01452567
Score: 0.624
Data Source: STRINGDB
EMP2
Tbio
Novelty: 0.00474286
Score: 0.621
Data Source: STRINGDB
C1QL3
Tbio
Novelty: 0.0465662
Score: 0.599
Data Source: STRINGDB
FBXL3
Tbio
Novelty: 0.07946915
Score: 0.572
Data Source: STRINGDB
GRM8
Tchem
Family: GPCR
Novelty: 0.00998475
Score: 0.551
Data Source: STRINGDB
APLNR
Tchem
Family: GPCR
Novelty: 0.001441
Score: 0.548
Data Source: STRINGDB
INSYN2B
Tdark
Novelty: 1.42857143
Score: 0.522
Data Source: STRINGDB
Publication Statistics
PubMed Score  14.42

PubMed score by year
PubTator Score  8.09

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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