Tbio ADGRB2 Adhesion G protein-coupled receptor B2

Protein Summary

Description

Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT-signaling pathway, a transcription factor, via the G-protein GNAZ (PubMed:20367554, PubMed:28891236). Involved in angiogenesis inhibition (By similarity). This gene encodes a a seven-span transmembrane protein that is thought to be a member of the secretin receptor family. The encoded protein is a brain-specific inhibitor of angiogenesis. The mature peptide may be further cleaved into additional products (PMID:20367554). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Uniprot Accession IDs

• O60241
• B9EGK9
• Q5T6K0
• Q8NGW8
• Q96GZ9

Gene Name

• ADGRB2

Ensembl ID

• ENST00000373655
• ENSP00000362759
• ENSG00000121753
• ENST00000373658
• ENSP00000362762
• ENST00000527361
• ENSP00000435397

Symbol

• BAI2
• BAI2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
PubMedID	0.76
transcription factor	0.72
transcription factor binding site profile	0.72
disease perturbation	0.62

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Adhesion G Protein-coupled Receptor B2

Protein / Defense/immunity Protein / Antibacterial Response Protein / Adhesion G Protein-coupled Receptor B2

Protein / ... / Protease / Adhesion G Protein-coupled Receptor B2

DTO Classes

Protein / G-protein Coupled Receptor / Adhesion Class / Adhesion G Protein-coupled Receptor B2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.14   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 256   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.14   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 256   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0