You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SH3BP5
SH3 domain-binding protein 5

Protein Summary
Description
Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000383791
  • ENSP00000373301
  • ENSG00000131370
  • ENST00000408919
  • ENSP00000386231
  • ENST00000426925
  • ENSP00000388553

Symbol
  • SAB
  • SAB
  • SH3BP-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
disease perturbation
0.83
PubMedID
0.77
disease
0.68
kinase perturbation
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.69   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.69   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (55)
RAB11B
Tbio
Family:  Enzyme
Novelty:  0.00557558
p_int:  0.999993218
p_ni:  3.9e-8
p_wrong:  0.000006744
Score:  0.312
Data Source:  BioPlex,STRINGDB
RAB11A
Tbio
Family:  Enzyme
Novelty:  0.00153551
p_int:  0.999956205
p_ni:  1.49e-7
p_wrong:  0.000043646
Score:  0.446
Data Source:  BioPlex,STRINGDB
BTK
Tclin
Family:  Kinase
Novelty:  0.00050747
Score:  0.994
Data Source:  STRINGDB
SYK
Tclin
Family:  Kinase
Novelty:  0.00058994
Score:  0.922
Data Source:  STRINGDB
LYN
Tclin
Family:  Kinase
Novelty:  0.00097393
Score:  0.92
Data Source:  STRINGDB
CD79A
Tbio
Novelty:  0.00118942
Score:  0.907
Data Source:  STRINGDB
BLNK
Tbio
Novelty:  0.00351169
Score:  0.906
Data Source:  STRINGDB
CD79B
Tclin
Novelty:  0.00227414
Score:  0.902
Data Source:  STRINGDB
BCL6
Tchem
Family:  TF
Novelty:  0.00066258
Score:  0.901
Data Source:  STRINGDB
BCR
Tclin
Novelty:  0.00127709
Score:  0.9
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SH3 domain binding protein 5
VGNC:8853
470759
Macaque
SH3 domain binding protein 5
717439
Mouse
MGI:1344391
24056
Rat
RGD:620220
117186
Dog
SH3 domain binding protein 5
VGNC:46120
485657
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SH3 domain binding protein 5
Macaque
SH3 domain binding protein 5
Mouse
Rat
Dog
SH3 domain binding protein 5
Publication Statistics
PubMed Score 169.69
PubMed score by year
PubTator Score 114.41
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title