Tbio SH3BP5 SH3 domain-binding protein 5

Protein Summary

Description

Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.

Uniprot Accession IDs

• O60239
• B3KQW6
• Q5JWV9
• SH3BP-5

Gene Name

• SH3BP5

Ensembl ID

• ENST00000383791
• ENSP00000373301
• ENSG00000131370
• ENST00000408919
• ENSP00000386231
• ENST00000426925
• ENSP00000388553

Symbol

• SAB
• SAB
• SH3BP-5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.91
disease perturbation	0.83
PubMedID	0.77
disease	0.68
kinase perturbation	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.13   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 147   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.13   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0