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Tbio
BNIP3L
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

Protein Summary
Description
Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain. The protein directly tar ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380629
  • ENSP00000370003
  • ENSG00000104765
  • ENST00000518611
  • ENSP00000429851
  • ENST00000520409
  • ENSP00000428597
  • ENST00000523515
  • ENSP00000429698

Symbol
  • BNIP3A
  • BNIP3H
  • NIX
  • NIX
  • BNIP3a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
0.99
virus perturbation
0.99
disease perturbation
0.97
transcription factor binding site profile
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.82   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 417   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.82   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 417   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
3
4
97.1
reticulocyte measurement
2
2
2
92.4
reticulocyte count
4
2
4
88.5
mean corpuscular hemoglobin concentration
1
1
1
76.1
4
3
1
1.1
74.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
97.1
reticulocyte measurement
2
92.4
reticulocyte count
4
88.5
mean corpuscular hemoglobin concentration
1
76.1
1
1.1
74.6
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BCL2 interacting protein 3 like
464069
Macaque
BCL2 interacting protein 3 like
641440
Mouse
MGI:1332659
12177
Rat
RGD:621354
140923
Horse
BCL2 interacting protein 3 like
VGNC:15858
100054317
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BCL2 interacting protein 3 like
Macaque
BCL2 interacting protein 3 like
Mouse
Rat
Horse
BCL2 interacting protein 3 like
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O60238-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (63)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
TP53 Regulates Transcription of Cell Death Genes
Reactome
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
TP53 Regulates Transcription of Cell Death Genes
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Protein-Protein Interactions (83)
1 – 10 of 83
BNIP3
Tbio
Novelty:  0.00216392
p_int:  0.999999999
p_ni:  1e-9
Score:  0.425
Data Source:  BioPlex,STRINGDB
WIPI2
Tbio
Novelty:  0.02685992
p_int:  0.999949008
p_ni:  9.91e-7
p_wrong:  0.00005
Score:  0.506
Data Source:  BioPlex,STRINGDB
STEAP3
Tbio
Family:  Enzyme
Novelty:  0.02042104
Score:  0.997
Data Source:  Reactome,STRINGDB
GABARAPL2
Tbio
Novelty:  0.0022546
Score:  0.957
Data Source:  STRINGDB
GABARAPL1
Tbio
Novelty:  0.00212657
Score:  0.954
Data Source:  STRINGDB
GABARAP
Tbio
Novelty:  0.00444901
Score:  0.954
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.943
Data Source:  STRINGDB
CREBBP
Tchem
Family:  Epigenetic
Novelty:  0.00111166
Score:  0.903
Data Source:  STRINGDB
BCL2L1
Tchem
Novelty:  0.00018414
Score:  0.838
Data Source:  STRINGDB
PKMYT1
Tchem
Family:  Kinase
Novelty:  0.03025516
Score:  0.807
Data Source:  STRINGDB
Publication Statistics
PubMed Score  181.82

PubMed score by year
PubTator Score  132.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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