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Tbio
PPP1R12B
Protein phosphatase 1 regulatory subunit 12B

Protein Summary
Description
Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus. Myosin phosphatase is a protein complex comprised of three subunits: a catalytic subunit (PP1c-delta, protein phosphatase 1, catalytic subunit delta), a large regulatory subunit (MYPT, myosin phosphatase target) and small regulatory subunit (sm-M20). Two isoforms of MYPT have been isolated--MYPT1 and MYPT2, the first of which is widely expressed, and the second of which may be specific to heart, skeletal muscle, and brain. Each of the MYPT isoforms functions to bind PP1c-delta and increase phosphatase activity. This locus encodes both MYTP2 and M20. Alternatively spliced transcript variants encoding different isoforms have been identified. Related pseudogenes have been defined on the Y chromosome. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290419
  • ENSP00000484005
  • ENSG00000077157
  • ENST00000356764
  • ENSP00000349206
  • ENST00000391959
  • ENSP00000375821
  • ENST00000480184
  • ENSP00000417159
  • ENST00000491336
  • ENSP00000480852
  • ENST00000608999
  • ENSP00000476755

Symbol
  • MYPT2
  • MYPT2
  • PP1bp55
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.83
transcription factor binding site profile
0.78
co-expressed gene
0.76
virus perturbation
0.64
phenotype
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.12   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 49   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.12   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex ratio
1
1
0
1.7
94
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex ratio
0
1.7
94
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
protein phosphatase 1 regulatory subunit 12B
705775
Mouse
MGI:1916417
329251
Rat
RGD:1309287
304813
Dog
protein phosphatase 1 regulatory subunit 12B
VGNC:44879
490230
Horse
protein phosphatase 1 regulatory subunit 12B
VGNC:21756
100063928
Species
Name
OMA
EggNOG
Inparanoid
Macaque
protein phosphatase 1 regulatory subunit 12B
Mouse
Rat
Dog
protein phosphatase 1 regulatory subunit 12B
Horse
protein phosphatase 1 regulatory subunit 12B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O60237-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (18)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
G2/M Transition
Reactome
Mitotic G2-G2/M phases
Reactome
RHO GTPase Effectors
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
G2/M Transition
Mitotic G2-G2/M phases
RHO GTPase Effectors
Protein-Protein Interactions (99)
1 – 10 of 99
NOTCH1
Tchem
Novelty: 0.00012547
p_int: 0.999999279
p_ni: 7.21e-7
Score: 0.156
Data Source: BioPlex,STRINGDB
ANK3
Tbio
Novelty: 0.00429246
p_int: 0.999997804
p_ni: 0.000002196
Data Source: BioPlex
TNKS2
Tchem
Family: Enzyme
Novelty: 0.00938509
p_int: 0.999997458
p_ni: 0.000002541
Data Source: BioPlex
HIF1AN
Tbio
Novelty: 0.00861018
p_int: 0.999994213
p_ni: 0.000005787
Score: 0.167
Data Source: BioPlex,STRINGDB
ASB1
Tdark
Novelty: 0.0931554
p_int: 0.999992337
p_ni: 0.000007072
p_wrong: 5.91e-7
Data Source: BioPlex
ASB3
Tbio
Novelty: 0.15921018
p_int: 0.999944813
p_ni: 0.000044344
p_wrong: 0.000010843
Data Source: BioPlex
FKBP6
Tbio
Family: Enzyme
Novelty: 0.02240256
p_int: 0.99989813
p_ni: 5e-9
p_wrong: 0.000101865
Score: 0.297
Data Source: BioPlex,STRINGDB
TNKS
Tchem
Family: Enzyme
Novelty: 0.00404545
p_int: 0.999883854
p_ni: 0.000116146
Data Source: BioPlex
ANK1
Tbio
Novelty: 0.00225305
p_int: 0.999761219
p_ni: 0.000087032
p_wrong: 0.000151749
Data Source: BioPlex
PPP1CB
Tbio
Family: Enzyme
Novelty: 0.0122614
p_int: 0.999725523
p_ni: 0.000274477
Score: 0.993
Data Source: BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score  22.12

PubMed score by year
PubTator Score  9.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer