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Tchem
TMPRSS11D
Transmembrane protease serine 11D

Protein Classes
Protein Summary
Description
May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate. This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000283916
  • ENSP00000283916
  • ENSG00000153802

Symbol
  • HAT
  • HAT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
cell type or tissue
0.84
gene perturbation
0.66
PubMedID
0.62
cell line
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 221.39   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 221.39   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 42
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (42)
1 – 10 of 42
CHEMBL1229259,CHEMBL1215083
chemical structure image
CHEMBL1809254
chemical structure image
CHEMBL1809251
chemical structure image
CHEMBL1809250
chemical structure image
CHEMBL1809241
chemical structure image
CHEMBL1809216
chemical structure image
CHEMBL1809213
chemical structure image
CHEMBL252937
chemical structure image
CHEMBL1809252
chemical structure image
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (25)
1 – 10 of 25
IL1RN
Tchem
Novelty: 0.00049281
Score: 0.634
Data Source: STRINGDB
HEXA
Tchem
Family: Enzyme
Novelty: 0.00302415
Score: 0.594
Data Source: STRINGDB
GFER
Tchem
Family: Enzyme
Novelty: 0.00073821
Score: 0.541
Data Source: STRINGDB
SERPINA5
Tbio
Family: Enzyme
Novelty: 0.0022031
Score: 0.533
Data Source: STRINGDB
ZBED1
Tbio
Family: TF
Novelty: 0.0064513
Score: 0.511
Data Source: STRINGDB
TLNRD1
Tdark
Novelty: 0.26086957
Score: 0.504
Data Source: STRINGDB
CCDC39
Tbio
Novelty: 0.02850725
Score: 0.503
Data Source: STRINGDB
TMCC1
Tbio
Novelty: 0.14596003
Score: 0.498
Data Source: STRINGDB
IFNK
Tbio
Novelty: 0.04124822
Score: 0.492
Data Source: STRINGDB
SPINT1
Tbio
Family: Enzyme
Novelty: 0.01180495
Score: 0.483
Data Source: STRINGDB
Publication Statistics
PubMed Score  221.39

PubMed score by year
PubTator Score  50.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer