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Tbio
DHX16
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16

Protein Summary
Description
Involved in pre-mRNA splicing. Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a functional homolog of fission yeast Prp8 protein involved in cell cycle progression. This gene is mapped to the MHC region on chromosome 6p21.3, a region where many malignant, genetic and autoimmune disease genes are linked. Three transcript variants encoding different isoforms have been found for this gene. [provided by Ref ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376442
  • ENSP00000365625
  • ENSG00000204560
  • ENST00000383577
  • ENSP00000373071
  • ENSG00000206486
  • ENST00000417308
  • ENSP00000390938
  • ENSG00000233561
  • ENST00000421095
  • ENSP00000396193
  • ENSG00000226171
  • ENST00000424672
  • ENSP00000389862
  • ENSG00000233418
  • ENST00000451456
  • ENSP00000408956
  • ENSG00000233049
  • ENST00000458094
  • ENSP00000393958
  • ENSG00000231377

Symbol
  • DBP2
  • DDX16
  • KIAA0577
  • PRP2
  • DBP2
  • PRP8
  • Prp2
  • DDX16
  • PRPF2
  • PRO2014
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
molecular function
0.99
interacting protein
0.97
protein domain
0.92
ligand (protein) perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.72   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 92   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.72   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
1
1
1
67.3
eosinophil count
1
1
1
67.3
eosinophil count
1
1
1
67.3
eosinophil count
1
1
1
67.3
eosinophil count
1
1
1
67.3
Items per page:
1 – 5 of 5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
1
67.3
eosinophil count
1
67.3
eosinophil count
1
67.3
eosinophil count
1
67.3
eosinophil count
1
67.3
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (6)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Gene Ontology Terms (10)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (319)
1 – 10 of 319
GPKOW
Tbio
Novelty: 0.14830491
p_int: 1
Score: 0.996
Data Source: BioPlex,STRINGDB
SETDB2
Tbio
Family: TF; Epigenetic
Novelty: 0.05560622
p_int: 0.99993934
p_ni: 0.00006066
Score: 0.284
Data Source: BioPlex,STRINGDB
CSNK2B
Tbio
Family: Kinase
Novelty: 0.00152367
p_int: 0.969906263
p_ni: 0.030093313
p_wrong: 4.24e-7
Score: 0.234
Data Source: BioPlex,STRINGDB
ZNF287
Tdark
Family: TF
Novelty: 1.01445884
p_int: 0.963340167
p_ni: 0.036659179
p_wrong: 6.55e-7
Data Source: BioPlex
TTC29
Tdark
Novelty: 0.1887357
p_int: 0.949656538
p_ni: 0.049803721
p_wrong: 0.000539741
Score: 0.232
Data Source: BioPlex,STRINGDB
CDKL5
Tchem
Family: Kinase
Novelty: 0.00444062
p_int: 0.904067179
p_ni: 0.095932821
Score: 0.234
Data Source: BioPlex,STRINGDB
FADS3
Tbio
Family: Enzyme
Novelty: 0.02899077
p_int: 0.903346232
p_ni: 0.096562438
p_wrong: 0.00009133
Score: 0.205
Data Source: BioPlex,STRINGDB
XAB2
Tbio
Novelty: 0.04104647
Score: 0.998
Data Source: STRINGDB
SF3B2
Tbio
Novelty: 0.0271365
Score: 0.996
Data Source: STRINGDB
SNRNP200
Tbio
Family: Enzyme
Novelty: 0.01339666
Score: 0.996
Data Source: STRINGDB
Publication Statistics
PubMed Score  38.72

PubMed score by year
PubTator Score  50.84

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer