DHX16
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16
Protein Summary
Involved in pre-mRNA splicing. Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a functional homolog of fission yeast Prp8 protein involved in cell cycle progression. This gene is mapped to the MHC region on chromosome 6p21.3, a region where many malignant, genetic and autoimmune disease genes are linked. Three transcript variants encoding different isoforms have been found for this gene. [provided by Ref ...more
- ENST00000376442
- ENSP00000365625
- ENSG00000204560
- ENST00000383577
- ENSP00000373071
- ENSG00000206486
- ENST00000417308
- ENSP00000390938
- ENSG00000233561
- ENST00000421095
- ENSP00000396193
- ENSG00000226171
- ENST00000424672
- ENSP00000389862
- ENSG00000233418
- ENST00000451456
- ENSP00000408956
- ENSG00000233049
- ENST00000458094
- ENSP00000393958
- ENSG00000231377
- DBP2
- DDX16
- KIAA0577
- PRP2
- DBP2
- PRP8
- Prp2
- DDX16
- PRPF2
- PRO2014
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.99 | ||
molecular function | 0.99 | ||
interacting protein | 0.97 | ||
protein domain | 0.92 | ||
ligand (protein) perturbation | 0.83 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 80 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 92 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 80 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 92 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0