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Tbio
KALRN
Kalirin

Protein Summary
Description
Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. [provided by RefSeq, Apr 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000240874
  • ENSP00000240874
  • ENSG00000160145
  • ENST00000291478
  • ENSP00000291478

Symbol
  • DUET
  • DUO
  • HAPIP
  • TRAD
  • DUO
  • CHD5
  • DUET
  • TRAD
  • CHDS5
  • HAPIP
  • ARHGEF24
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.96
trait
0.93
transcription factor perturbation
0.88
virus perturbation
0.76


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.92   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 158   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.92   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
5
7
95.7
cognitive function measurement
1
1
1
76.5
platelet count
2
4
4
71.9
monocyte count
2
2
2
67.7
self reported educational attainment
1
1
1
63.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
7
95.7
cognitive function measurement
1
76.5
platelet count
4
71.9
monocyte count
2
67.7
self reported educational attainment
1
63.6
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
trio Rho guanine nucleotide exchange factor
717492
Mouse
MGI:2685385
545156
Rat
RGD:621865
84009
Dog
kalirin RhoGEF kinase
VGNC:42200
478592
Horse
kalirin RhoGEF kinase
VGNC:19234
100060560
Species
Name
OMA
EggNOG
Inparanoid
Macaque
trio Rho guanine nucleotide exchange factor
Mouse
Rat
Dog
kalirin RhoGEF kinase
Horse
kalirin RhoGEF kinase
Protein Structure (0 Structures, 9 AlphaFold Models)
RepresentationColor Scheme

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (21)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cell death signalling via NRAGE, NRIF and NADE
Reactome
Death Receptor Signalling
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Name
Explore in Pharos
Explore in Source
Axon guidance
Cell death signalling via NRAGE, NRIF and NADE
Death Receptor Signalling
Developmental Biology
EPH-Ephrin signaling
Gene Ontology Terms (30)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (246)
1 – 10 of 246
RAC1
Tbio
Family: Enzyme
Novelty: 0.00365325
Score: 0.987
Data Source: Reactome,STRINGDB
RAC2
Tbio
Family: Enzyme
Novelty: 0.00116234
Score: 0.986
Data Source: STRINGDB
RAC3
Tbio
Family: Enzyme
Novelty: 0.02125361
Score: 0.986
Data Source: STRINGDB
CDC42
Tchem
Family: Enzyme
Novelty: 0.00032619
Score: 0.982
Data Source: STRINGDB
RHOA
Tbio
Family: Enzyme
Novelty: 0.00022204
Score: 0.969
Data Source: STRINGDB
EPHB2
Tchem
Family: Kinase
Novelty: 0.00211785
Score: 0.967
Data Source: STRINGDB
RHOG
Tbio
Family: Enzyme
Novelty: 0.00412327
Score: 0.965
Data Source: STRINGDB
RHOD
Tbio
Family: Enzyme
Novelty: 0.0029764
Score: 0.953
Data Source: STRINGDB
RHOC
Tbio
Family: Enzyme
Novelty: 0.00262213
Score: 0.952
Data Source: STRINGDB
RHOB
Tbio
Family: Enzyme
Novelty: 0.0019205
Score: 0.949
Data Source: STRINGDB
Publication Statistics
PubMed Score  111.92

PubMed score by year
PubTator Score  49.05

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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