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Tbio
SSX4
Protein SSX4

Protein Summary
Description
Could act as a modulator of transcription. The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. Chromosome Xp11 contains a segmental duplication resulting in two identical copies of synovial sarcoma, X breakpoint 4, SSX4 and SSX4B, in tail-to-tail orientation. This gene, SSX4B, represents the more centromeric copy. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 200 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000595235
  • ENSP00000469394
  • ENSG00000269791
  • ENST00000595689
  • ENSP00000469011
  • ENSG00000268009
  • ENST00000619890
  • ENSP00000481765
  • ENST00000620320
  • ENSP00000483262

Symbol
  • SSX4A
  • CT5.4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.46
protein complex
0.4
disease
0.37
biological term
0.35
PubMedID
0.24


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.32   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.32   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (38)
1 – 10 of 38
SSX2IP
Tbio
Novelty: 0.01381625
Score: 0.839
Data Source: STRINGDB
SS18
Tbio
Novelty: 0.00915548
Score: 0.821
Data Source: STRINGDB
SS18L2
Tdark
Novelty: 1.37000973
Score: 0.745
Data Source: STRINGDB
SS18L1
Tbio
Novelty: 0.10255799
Score: 0.716
Data Source: STRINGDB
MAGEC1
Tbio
Novelty: 0.01123023
Score: 0.7
Data Source: STRINGDB
MAGEA4
Tbio
Novelty: 0.00949096
Score: 0.683
Data Source: STRINGDB
MAGEA3
Tbio
Novelty: 0.00285779
Score: 0.677
Data Source: STRINGDB
MAGEA1
Tbio
Novelty: 0.00506874
Score: 0.677
Data Source: STRINGDB
CTAG2
Tbio
Novelty: 0.02983879
Score: 0.67
Data Source: STRINGDB
CTAG1A
Tbio
Novelty: 0.00345306
Score: 0.67
Data Source: STRINGDB
Publication Statistics
PubMed Score  14.32

PubMed score by year
PubTator Score  0.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer