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Tbio
TIMM8A
Mitochondrial import inner membrane translocase subunit Tim8 A

Protein Summary
Description
Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. Probably necessary for normal neurologic development. This translocase is involved in the import and insertion of hydrophobic membrane proteins from the cytoplasm into the mitochondrial inner membrane. The gene is mutated in Mohr-Tranebjaerg syndrome/Deafness Dystonia Syndrome (MTS/DDS) and it is postulated that MTS/DDS is ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372902
  • ENSP00000361993
  • ENSG00000126953
  • ENST00000647359
  • ENSP00000494465

Symbol
  • DDP
  • DDP1
  • TIM8A
  • DDP
  • MTS
  • DDP1
  • DFN1
  • TIM8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
disease perturbation
0.83
kinase perturbation
0.76
histone modification site profile
0.64
cellular component
0.61


Related Tools
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.99   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.99   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
translocase of inner mitochondrial membrane 8A
VGNC:14722
738690
Mouse
MGI:1353433
30058
Dog
translocase of inner mitochondrial membrane 8A
VGNC:49623
480986
Cow
translocase of inner mitochondrial membrane 8A
VGNC:49578
515109
Opossum
translocase of inner mitochondrial membrane 8A
100618232
Species
Name
OMA
EggNOG
Inparanoid
Chimp
translocase of inner mitochondrial membrane 8A
Mouse
Dog
translocase of inner mitochondrial membrane 8A
Cow
translocase of inner mitochondrial membrane 8A
Opossum
translocase of inner mitochondrial membrane 8A
Pathways (2)
Mitochondrial protein import (R-HSA-1268020)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial protein import
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Mitochondrial protein import
Protein localization
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (143)
1 – 10 of 143
ATP23
Tbio
Family: Enzyme
Novelty: 0.09823059
p_int: 0.999999156
p_ni: 8.31e-7
p_wrong: 1.3e-8
Score: 0.489
Data Source: BioPlex,STRINGDB
FAM210B
Tbio
Novelty: 0.19704434
p_int: 0.999997518
p_ni: 0.000002482
Data Source: BioPlex
RAVER2
Tbio
Novelty: 0.35773243
p_int: 0.999991216
p_ni: 0.000008777
p_wrong: 7e-9
Data Source: BioPlex
PAQR4
Tdark
Novelty: 0.19162213
p_int: 0.999989749
p_ni: 9.8e-8
p_wrong: 0.000010153
Data Source: BioPlex
C22orf39
Tdark
Novelty: 1.13707647
p_int: 0.999987182
p_ni: 0.000004612
p_wrong: 0.000008206
Data Source: BioPlex
ZNF282
Tdark
Family: TF
Novelty: 0.32333465
p_int: 0.998932555
p_ni: 0.001065738
p_wrong: 0.000001707
Data Source: BioPlex
MT-ATP8
Tbio
Family: Enzyme
Novelty: 0.00249065
p_int: 0.99801293
p_ni: 0.001973855
p_wrong: 0.000013215
Data Source: BioPlex
ARNT
Tbio
Family: TF
Novelty: 0.00183071
p_int: 0.997876496
p_ni: 0.002123504
Data Source: BioPlex
ERCC6L
Tbio
Novelty: 0.01959203
p_int: 0.995270171
p_ni: 0.00472771
p_wrong: 0.000002119
Data Source: BioPlex
TIMM13
Tdark
Family: Enzyme
Novelty: 0.04802297
p_int: 0.995074569
p_ni: 0.004925431
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score  108.99

PubMed score by year
PubTator Score  102.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer