AKR1B10
Aldo-keto reductase family 1 member B10
Protein Summary
Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. [provided by RefSeq, Jul 2008]
- ENST00000359579
- ENSP00000352584
- ENSG00000198074
- AKR1B11
- HIS
- HSI
- ARL1
- ARL-1
- ALDRLn
- AKR1B11
- AKR1B12
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.99 | ||
transcription factor perturbation | 0.99 | ||
virus perturbation | 0.9 | ||
chemical | 0.84 | ||
kinase perturbation | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 270.83 (req: < 5)
Gene RIFs: 111 (req: <= 3)
Antibodies: 345 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 270.83 (req: >= 5)
Gene RIFs: 111 (req: > 3)
Antibodies: 345 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 59
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 3