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Tchem
AKR1B10
Aldo-keto reductase family 1 member B10

Protein Summary
Description
Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359579
  • ENSP00000352584
  • ENSG00000198074

Symbol
  • AKR1B11
  • HIS
  • HSI
  • ARL1
  • ARL-1
  • ALDRLn
  • AKR1B11
  • AKR1B12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
transcription factor perturbation
0.99
virus perturbation
0.9
chemical
0.84
kinase perturbation
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 232.9   (req: < 5)
Gene RIFs: 80   (req: <= 3)
Antibodies: 345   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 232.9   (req: >= 5)
Gene RIFs: 80   (req: > 3)
Antibodies: 345   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 59
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (59)
Oleanoic acid
Rendered image for Oleanoic acid
CHEMBL4081954
Rendered image for CHEMBL4081954
CHEMBL4089817
Rendered image for CHEMBL4089817
zopolrestat
Rendered image for zopolrestat
Minalrestat
Rendered image for Minalrestat
CHEMBL2440411
Rendered image for CHEMBL2440411
CHEMBL1172665
Rendered image for CHEMBL1172665
Protein-Protein Interactions (91)
AKR1B15
Tbio
Family:  Enzyme
Novelty:  0.29076067
p_int:  0.999999999
p_ni:  1e-9
Score:  0.528
Data Source:  BioPlex,STRINGDB
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.998725958
p_ni:  0.001274042
p_wrong:  1e-9
Data Source:  BioPlex
CDK15
Tchem
Family:  Kinase
Novelty:  0.3870338
p_int:  0.99680198
p_ni:  0.00319802
Data Source:  BioPlex
DDX19B
Tbio
Family:  Enzyme
Novelty:  0.0504568
p_int:  0.994669446
p_ni:  0.005330554
Data Source:  BioPlex
AKR1D1
Tbio
Family:  Enzyme
Novelty:  0.01264297
p_int:  0.9731707
p_ni:  0.026802638
p_wrong:  0.000026662
Score:  0.282
Data Source:  BioPlex,STRINGDB
POTEF
Tbio
Novelty:  0.00191599
p_int:  0.960028848
p_ni:  0.039971152
Score:  0.199
Data Source:  BioPlex,STRINGDB
PCBP3
Tbio
Novelty:  0.11681812
p_int:  0.944141836
p_ni:  0.045819633
p_wrong:  0.010038531
Score:  0.268
Data Source:  BioPlex,STRINGDB
PDE4DIP
Tbio
Novelty:  0.03414104
p_int:  0.93372474
p_ni:  0.066196187
p_wrong:  0.000079073
Data Source:  BioPlex
SORD
Tchem
Family:  Enzyme
Novelty:  0.0040485
Score:  0.956
Data Source:  STRINGDB
DHDH
Tbio
Family:  Enzyme
Novelty:  0.00284827
Score:  0.955
Data Source:  STRINGDB
Pathways (21)
G alpha (i) signalling events (R-HSA-418594)

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Items per page:
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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Metabolism
Reactome
Metabolism of fat-soluble vitamins
Reactome
Metabolism of vitamins and cofactors
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
Metabolism
Metabolism of fat-soluble vitamins
Metabolism of vitamins and cofactors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
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Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
1
1
61.4
Agents acting on the renin-angiotensin system use measurement
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
61.4
Agents acting on the renin-angiotensin system use measurement
1
39.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (2)
Publication Statistics
PubMed Score 232.90
PubMed score by year
PubTator Score 158.35
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title