You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RAD21
Double-strand-break repair protein rad21 homolog

Protein Summary
Description
Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway. The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297338
  • ENSP00000297338
  • ENSG00000164754

Symbol
  • HR21
  • KIAA0078
  • NXP1
  • SCC1
  • MGS
  • HR21
  • MCD1
  • NXP1
  • SCC1
  • CDLS4
  • hHR21
  • HRAD21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.98
virus perturbation
0.98
disease perturbation
0.79
protein complex
0.75
transcription factor binding site profile
0.75


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 393.29   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 270   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 393.29   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 270   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAD21 cohesin complex component
VGNC:812
464346
Macaque
RAD21 cohesin complex component
700633
Mouse
MGI:108016
19357
Rat
RGD:1594529
314949
Dog
RAD21 cohesin complex component
VGNC:45313
482021
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAD21 cohesin complex component
Macaque
RAD21 cohesin complex component
Mouse
Rat
Dog
RAD21 cohesin complex component
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O60216-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (1085)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cohesin Loading onto Chromatin
Reactome
ESR-mediated signaling
Reactome
Establishment of Sister Chromatid Cohesion
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Cohesin Loading onto Chromatin
ESR-mediated signaling
Establishment of Sister Chromatid Cohesion
Protein-Protein Interactions (364)
1 – 10 of 364
STAG1
Tbio
Novelty: 0.00122511
p_int: 0.999999994
p_ni: 6e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
STAG2
Tbio
Novelty: 0.00430441
p_int: 0.99999999
p_ni: 1e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
WAPL
Tbio
Novelty: 0.01598061
p_int: 0.999999187
p_ni: 8.13e-7
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
USP13
Tchem
Family: Enzyme
Novelty: 0.03470844
p_int: 0.999994595
p_ni: 4.7e-8
p_wrong: 0.000005359
Score: 0.188
Data Source: BioPlex,STRINGDB
CDCA5
Tbio
Novelty: 0.02255012
p_int: 0.999987008
p_ni: 0.000012992
Score: 0.993
Data Source: BioPlex,STRINGDB
SMC1B
Tbio
Novelty: 0.0369537
p_int: 0.999986514
p_ni: 0.000013474
p_wrong: 1.1e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
PDS5A
Tbio
Novelty: 0.0142948
p_int: 0.999921646
p_ni: 0.000078354
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
SMC3
Tbio
Novelty: 0.00474377
p_int: 0.999910763
p_ni: 0.000089237
Score: 0.999
Data Source: BioPlex,STRINGDB
CITED1
Tbio
Novelty: 0.01956689
p_int: 0.99979397
p_ni: 0.00020603
Data Source: BioPlex
SMC1A
Tbio
Novelty: 0.00898427
p_int: 0.999720386
p_ni: 0.000279614
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  393.29

PubMed score by year
PubTator Score  224.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer