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Tbio
RAD21
Double-strand-break repair protein rad21 homolog

Protein Summary
Description
Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway. The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297338
  • ENSP00000297338
  • ENSG00000164754

Symbol
  • HR21
  • KIAA0078
  • NXP1
  • SCC1
  • MGS
  • HR21
  • MCD1
  • NXP1
  • SCC1
  • CDLS4
  • hHR21
  • HRAD21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.98
virus perturbation
0.98
disease perturbation
0.79
protein complex
0.75
transcription factor binding site profile
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 402.58   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 270   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 402.58   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 270   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (364)
STAG1
Tbio
Novelty:  0.00122511
p_int:  0.999999994
p_ni:  6e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
STAG2
Tbio
Novelty:  0.00430441
p_int:  0.99999999
p_ni:  1e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
WAPL
Tbio
Novelty:  0.01598061
p_int:  0.999999187
p_ni:  8.13e-7
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
USP13
Tchem
Family:  Enzyme
Novelty:  0.03470844
p_int:  0.999994595
p_ni:  4.7e-8
p_wrong:  0.000005359
Score:  0.188
Data Source:  BioPlex,STRINGDB
CDCA5
Tbio
Novelty:  0.02255012
p_int:  0.999987008
p_ni:  0.000012992
Score:  0.993
Data Source:  BioPlex,STRINGDB
SMC1B
Tbio
Novelty:  0.0369537
p_int:  0.999986514
p_ni:  0.000013474
p_wrong:  1.1e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
PDS5A
Tbio
Novelty:  0.0142948
p_int:  0.999921646
p_ni:  0.000078354
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
SMC3
Tbio
Novelty:  0.00474377
p_int:  0.999910763
p_ni:  0.000089237
Score:  0.999
Data Source:  BioPlex,STRINGDB
CITED1
Tbio
Novelty:  0.01956689
p_int:  0.99979397
p_ni:  0.00020603
Data Source:  BioPlex
SMC1A
Tchem
Novelty:  0.00898427
p_int:  0.999720386
p_ni:  0.000279614
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (1085)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cohesin Loading onto Chromatin
Reactome
ESR-mediated signaling
Reactome
Establishment of Sister Chromatid Cohesion
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Cohesin Loading onto Chromatin
ESR-mediated signaling
Establishment of Sister Chromatid Cohesion
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.4
78.7
1
1
0
1.2
66.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
78.7
0
1.2
66.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAD21 cohesin complex component
VGNC:812
464346
Macaque
RAD21 cohesin complex component
700633
Mouse
MGI:108016
19357
Rat
RGD:1594529
314949
Dog
RAD21 cohesin complex component
VGNC:45313
482021
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAD21 cohesin complex component
Macaque
RAD21 cohesin complex component
Mouse
Rat
Dog
RAD21 cohesin complex component
Publication Statistics
PubMed Score 402.58
PubMed score by year
PubTator Score 224.31
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title