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Tbio
ORC4
Origin recognition complex subunit 4

Protein Summary
Description
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3. The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. This gene encodes a subunit of the ORC complex. Several alternatively spliced transcript variants, some of which encode the same protein, have been reported for this gene. [provided by RefSeq, Oct 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264169
  • ENSP00000264169
  • ENSG00000115947
  • ENST00000392857
  • ENSP00000376597
  • ENST00000535373
  • ENSP00000441953
  • ENST00000536575
  • ENSP00000441502
  • ENST00000540442
  • ENSP00000438326

Symbol
  • ORC4L
  • ORC4L
  • ORC4P
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.86
transcription factor binding site profile
0.81
transcription factor
0.8
histone modification site profile
0.79
kinase perturbation
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.65   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 223   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.65   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 223   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
3
3
2
5.9
95.2
sex hormone-binding globulin measurement
2
1
2
76.2
basophil count
1
1
1
73.5
glomerular filtration rate
2
2
2
59.6
uric acid measurement
1
1
1
32.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
2
5.9
95.2
sex hormone-binding globulin measurement
2
76.2
basophil count
1
73.5
glomerular filtration rate
2
59.6
uric acid measurement
1
32.2
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
origin recognition complex subunit 4
VGNC:14334
459647
Macaque
origin recognition complex subunit 4
721876
Mouse
MGI:1347043
26428
Rat
RGD:735212
295596
Dog
origin recognition complex subunit 4
VGNC:44143
476141
Species
Name
OMA
EggNOG
Inparanoid
Chimp
origin recognition complex subunit 4
Macaque
origin recognition complex subunit 4
Mouse
Rat
Dog
origin recognition complex subunit 4
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O43929-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (24)
Activation of ATR in response to replication stress (R-HSA-176187)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of ATR in response to replication stress
Reactome
Activation of the pre-replicative complex
Reactome
Assembly of the ORC complex at the origin of replication
Reactome
Assembly of the pre-replicative complex
Reactome
CDC6 association with the ORC:origin complex
Name
Explore in Pharos
Explore in Source
Activation of ATR in response to replication stress
Activation of the pre-replicative complex
Assembly of the ORC complex at the origin of replication
Assembly of the pre-replicative complex
CDC6 association with the ORC:origin complex
Gene Ontology Terms (13)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (141)
1 – 10 of 141
LACC1
Tbio
Family: Enzyme
Novelty: 0.03928871
p_int: 0.984739744
p_ni: 0.015129584
p_wrong: 0.000130672
Score: 0.226
Data Source: BioPlex,STRINGDB
CD93
Tbio
Novelty: 0.01324003
p_int: 0.908632688
p_ni: 0.091367312
Score: 0.188
Data Source: BioPlex,STRINGDB
LAMP1
Tbio
Novelty: 0.00067563
p_int: 0.904336616
p_ni: 0.095663384
Score: 0.163
Data Source: BioPlex,STRINGDB
DLK1
Tchem
Novelty: 0.00212394
p_int: 0.893587878
p_ni: 0.106412122
Data Source: BioPlex
IL1R2
Tbio
Novelty: 0.00820359
p_int: 0.787255781
p_ni: 0.212744219
Data Source: BioPlex
TXNDC15
Tdark
Novelty: 0.23488442
p_int: 0.780311622
p_ni: 0.219688378
Data Source: BioPlex
P2RX4
Tchem
Family: IC
Novelty: 0.00242958
p_int: 0.751069607
p_ni: 0.248930393
Score: 0.163
Data Source: BioPlex,STRINGDB
MCM6
Tbio
Novelty: 0.00675724
Score: 0.999
Data Source: STRINGDB
ORC2
Tbio
Novelty: 0.11963517
Score: 0.999
Data Source: Reactome,STRINGDB
ORC6
Tbio
Novelty: 0.02529139
Score: 0.999
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  54.65

PubMed score by year
PubTator Score  16.41

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer