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Tclin
PDE6D
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

Protein Summary
Description
Promotes the release of prenylated target proteins from cellular membranes (PubMed:9712853). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (PubMed:22002721, PubMed:23698361). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (PubMed:24166846). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate (By similarity). This gene encodes the delta subunit of rod-specific photoreceptor phosphodiesterase (PDE), a key enzyme in the phototransduction cascade. A similar protein in cow functions in solubilizing membrane-bound PDE. In addition to its role in the PDE complex, the encoded protein is thought to bind to prenyl groups of proteins to target them to subcellular organelles called ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287600
  • ENSP00000287600
  • ENSG00000156973

Symbol
  • PDED
  • PDED
  • JBTS22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
transcription factor perturbation
0.84
transcription factor binding site profile
0.8
disease perturbation
0.79
molecular function
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.88   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.88   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 122
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
1 – 1 of 1
dipyridamole
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Protein-Protein Interactions (110)
1 – 10 of 110
RPGR
Tbio
Family:  Enzyme
Novelty:  0.002733
p_int:  0.996519116
p_ni:  0.003480877
p_wrong:  6e-9
Score:  0.955
Data Source:  BioPlex,STRINGDB
DNAJC11
Tbio
Novelty:  0.31080011
p_int:  0.954569284
p_ni:  0.045392298
p_wrong:  0.000038418
Score:  0.228
Data Source:  BioPlex,STRINGDB
C6orf141
Tdark
Novelty:  1.46022784
p_int:  0.918172323
p_ni:  0.081827619
p_wrong:  5.8e-8
Data Source:  BioPlex
TALDO1
Tbio
Family:  Enzyme
Novelty:  0.00208619
p_int:  0.88931388
p_ni:  0.110686089
p_wrong:  3.1e-8
Score:  0.555
Data Source:  BioPlex,STRINGDB
ARL13B
Tbio
Family:  Enzyme
Novelty:  0.01481674
Score:  0.987
Data Source:  Reactome,STRINGDB
ARL3
Tbio
Family:  Enzyme
Novelty:  0.01954965
Score:  0.95
Data Source:  STRINGDB
INPP5E
Tbio
Family:  Enzyme
Novelty:  0.04539038
Score:  0.947
Data Source:  Reactome,STRINGDB
RHEB
Tbio
Family:  Enzyme
Novelty:  0.00313935
Score:  0.911
Data Source:  STRINGDB
ARL2
Tbio
Family:  Enzyme
Novelty:  0.01989908
Score:  0.875
Data Source:  STRINGDB
ALDH7A1
Tbio
Family:  Enzyme
Novelty:  0.00069494
Score:  0.755
Data Source:  STRINGDB
Pathways (9)
ARL13B-mediated ciliary trafficking of INPP5E (R-HSA-5624958)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ARL13B-mediated ciliary trafficking of INPP5E
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Cilium Assembly
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
ARL13B-mediated ciliary trafficking of INPP5E
Cargo trafficking to the periciliary membrane
Cilium Assembly
Organelle biogenesis and maintenance
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
2
2
2
73
myeloid white cell count
1
1
1
38.8
lymphocyte count
3
1
3
38.7
neutrophil count
2
1
2
14
monocyte percentage of leukocytes
1
1
1
12.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
2
73
myeloid white cell count
1
38.8
lymphocyte count
3
38.7
neutrophil count
2
14
monocyte percentage of leukocytes
1
12.3
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphodiesterase 6D
VGNC:2751
738319
Mouse
MGI:1270843
18582
Dog
phosphodiesterase 6D
VGNC:44360
403781
Horse
phosphodiesterase 6D
VGNC:21251
100630114
Cow
phosphodiesterase 6D
VGNC:32682
281976
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphodiesterase 6D
Mouse
Dog
phosphodiesterase 6D
Horse
phosphodiesterase 6D
Cow
phosphodiesterase 6D
Publication Statistics
PubMed Score 35.88
PubMed score by year
PubTator Score 11.23
PubTator score by year